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Seeing is
Believing
Explore how our experts can help you.
Visualize your structures with cryo-EM.
3D Reconstruction
NIS uses cryo-EM & advanced data processing to generate high resolution 3D maps & models of challenging molecules and membrane proteins, over 76% below 3.5Å.
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2D Class Averaging
2D classificationwhen individual particles from TEM images are selected, aligned, and computationally averaged, providing information on particle flexibility.
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Negative Stain Screening
Negative stain screening provides rapid assessment of particle size, morphology, aggregation, heterogeneity, antibody interactions and higher order structure.
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Encapsulation Efficiency
Encapsulation efficiency is critical in design of drug delivery systems. Explore how NIS deploys cryo-TEM to demonstrate structural parameters of nanoparticles.
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Particle Morphology & Lamellarity
Cryo-TEM for lamellarity & particle morphology analysis provides important structural details on a per-particle basis that cannot be captured by other methods.
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Absolute Configuration
MicroED can determine the absolute configuration within a molecule through relative configuration to a known stereocenter or by employing dynamical refinement.
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Particle Size Distribution
Particle size distribution analysis of cryo-TEM images provides precise distribution measurement for nanometer to sub-micron particles in samples.
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Single Particle Analysis
Cryo-EM is widely adopted for drug target structural enablement. Explore cryo-EM single particle analysis capabilities for your structural biology applications.
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Particle Titer Determination
Determining particle titer and ratio of empty to fully packaged capsids with cryo-TEM is important for development and monitoring of viral vector preparations.
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Powder X-Ray Diffraction
Powder X-ray diffraction (PXRD) can quickly tell if a sample is crystalline and therefore suitable for structure determination by MicroED.
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Small Molecule Crystal Structure Determination
MicroED provides alternatives to growing large crystals as small molecules readily form microcrystalline powders suitable for crystal structure determination.
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