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Seeing is
Believing
Explore how our experts can help you.
Visualize your structures with cryo-EM.
2D Class Averaging
Cryo-EM can be used for the 2D classification of individual particles from TEM images and to visualize particle flexibility.
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3D Structure Reconstruction
Use cryo-EM & advanced data processing to generate high resolution 3D maps & models of challenging molecules and membrane proteins, over 76% below 3.5Å.
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Absolute Configuration
MicroED can determine the absolute configuration within a molecule through relative configuration to a known stereocenter or by employing dynamical refinement.
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Cryo-Electron Tomography
Cryoelectron tomography (Cryo-ET) allows for 3D analysis of particles in the nanometer to sub-micron range that lack uniform particle morphology.
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Encapsulation Efficiency
Encapsulation efficiency is critical in design of drug delivery systems. Cryo-TEM can demonstrate structural parameters of nanoparticles and visualize mRNA or DNA encapsulation.
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Negative Stain Screening
Negative stain screening provides rapid assessment of particle size, morphology, aggregation, heterogeneity, antibody interactions and higher order structure.
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Particle Morphology & Lamellarity
Cryo-TEM can be used to visualize lamellarity & particle morphology analysis provides important structural details on a per-particle basis.
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Particle Size Distribution
Particle size distribution analysis of cryo-TEM images provides precise distribution measurement for nanoparticle samples.
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Particle Titer Determination
Determining particle titer and ratio of empty to fully packaged capsids with cryo-TEM for development and monitoring of viral vector preparations.
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Powder X-Ray Diffraction
Powder X-ray diffraction (PXRD) can quickly tell if a sample is crystalline and therefore suitable for structure determination by MicroED.
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Single Particle Analysis (SPA)
Get accurate and reliable high resolution protein structure determination with cryo-EM single particle analysis techniques.
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Small Molecule Crystal Structure Determination
MicroED provides alternatives to growing large crystals as small molecules readily form microcrystalline powders suitable for crystal structure determination.
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