Analyses

NIS uses cryo-EM & advanced data processing to generate high resolution 3D maps & models of challenging molecules and membrane proteins, over 76% below 3.5Å.

2D classificationwhen individual particles from TEM images are selected, aligned, and computationally averaged, providing information on particle flexibility.

Negative stain screening provides rapid assessment of particle size, morphology, aggregation, heterogeneity, antibody interactions and higher order structure.

Encapsulation efficiency is critical in design of drug delivery systems. Explore how NIS deploys cryo-TEM to demonstrate structural parameters of nanoparticles.

Cryo-TEM for lamellarity & particle morphology analysis provides important structural details on a per-particle basis that cannot be captured by other methods.

MicroED can determine the absolute configuration within a molecule through relative configuration to a known stereocenter or by employing dynamical refinement.

Particle size distribution analysis of cryo-TEM images provides precise distribution measurement for nanometer to sub-micron particles in samples.

Cryo-EM is widely adopted for drug target structural enablement. Explore cryo-EM single particle analysis capabilities for your structural biology applications.

Determining particle titer and ratio of empty to fully packaged capsids with cryo-TEM is important for development and monitoring of viral vector preparations.

Powder X-ray diffraction (PXRD) can quickly tell if a sample is crystalline and therefore suitable for structure determination by MicroED.

MicroED provides alternatives to growing large crystals as small molecules readily form microcrystalline powders suitable for crystal structure determination.