Analyses

NIS expertly deploys cryo-EM and advanced data processing generate high resolution 3D maps and models of challenging molecules. More than half of the structures we've solved are membrane proteins and more than 76% of our structures are below 3.5Å resolution.

2D classification is a process by which individual particles from TEM images (cryo or NS) are selected, aligned relative to each other, and computationally averaged. 2D classes provide information on particle flexibility, features, as well as on domain structures.

Our negative stain screening services provide rapid assessments of particle size, symmetry, morphology, degree of aggregation, conformational and compositional heterogeneity, antibody interactions and higher order structure.

Encapsulation efficiency is critical in the design of drug delivery systems. Explore how NIS deploys cryo-TEM to demonstrate structural parameters of nanoparticles.

Cryo-TEM for lamellarity and particle morphology analysis provides important structural details on a per-particle basis that cannot be captured by other methods.

MicroED is able to determine the absolute configuration (stereochemistry of all chiral centers) within a molecule either through relative configuration to a known stereocenter or by employing dynamical refinement.

Particle size distribution analysis of cryo-TEM images provides precise distribution measurement for nanometer to sub-micron particles in heterogeneous and homogeneous samples.

Cryo-EM is widely adopted for drug target structural enablement. Explore our cryo-EM single particle analysis capabilities for your structural biology applications.

Determining particle titer and the ratio of empty to fully packaged capsids with cryo-TEM is important for development and monitoring of viral vector preparations.

Powder X-ray diffraction (PXRD) can quickly tell if a sample is crystalline and therefore suitable for structure determination by MicroED.

Growing large crystals for single crystal X-ray diffraction (scXRD) can be challenging. MicroED provides an attractive alternative as many small molecules readily form microcrystalline powders suitable for crystal structure determination by MicroED.