Analyses

Cryo-EM can be used for the 2D classification of individual particles from TEM images and to visualize particle flexibility.

Use cryo-EM & advanced data processing to generate high resolution 3D maps & models of challenging molecules and membrane proteins, over 76% below 3.5Å.

MicroED can determine the absolute configuration within a molecule through relative configuration to a known stereocenter or by employing dynamical refinement.

Cryoelectron tomography (Cryo-ET) allows for 3D analysis of particles in the nanometer to sub-micron range that lack uniform particle morphology.

Encapsulation efficiency is critical in design of drug delivery systems. Cryo-TEM can demonstrate structural parameters of nanoparticles and visualize mRNA or DNA encapsulation.

Negative stain screening provides rapid assessment of particle size, morphology, aggregation, heterogeneity, antibody interactions and higher order structure.

Cryo-TEM can be used to visualize lamellarity & particle morphology analysis provides important structural details on a per-particle basis.

Particle size distribution analysis of cryo-TEM images provides precise distribution measurement for nanoparticle samples.

Determining particle titer and ratio of empty to fully packaged capsids with cryo-TEM for development and monitoring of viral vector preparations.

Powder X-ray diffraction (PXRD) can quickly tell if a sample is crystalline and therefore suitable for structure determination by MicroED.

Get accurate and reliable high resolution protein structure determination with cryo-EM single particle analysis techniques.

MicroED provides alternatives to growing large crystals as small molecules readily form microcrystalline powders suitable for crystal structure determination.