Analyses

Cryo-EM or negative stain imaging can be used for the 2D classification of individual particles from TEM micrographs to classify particles, and visualize particle flexibility.

Use cryo-EM & advanced data processing to generate high resolution 3D maps & models of challenging molecules and membrane proteins, over 76% below 3.5Å.

Cryoelectron tomography (Cryo-ET) allows for 3D analysis of particles in the nanometer to sub-micron range that lack uniform particle morphology.

Encapsulation efficiency is critical in design of drug delivery systems. Cryo-TEM can demonstrate structural parameters of nanoparticles and visualize mRNA or DNA encapsulation.

Cryo-EM & negative stain TEM can be used to assess the binding interactions of antibody-antigen complexes. Explore how TEM can elucidate Fab binding across a range of resolutions.

Quickly visualize your protein or drug target in under two weeks to better assess the next steps in your single particle or structure based drug design workflow.

Negative stain screening provides rapid assessment of particle size, morphology, aggregation, heterogeneity, antibody interactions and higher order structure.

Cryo-TEM can be used to visualize lamellarity & particle morphology analysis provides important structural details on a per-particle basis.

Directly visualize characteristics including payload location and density, lamellarity analysis, and antigen distribution with cryo-TEM imaging and automated per-particle analysis.

Particle size distribution analysis of cryo-TEM images provides precise distribution measurement for nanoparticle samples.

Determine particle titer and ratio of empty to fully packaged capsids with cryo-TEM for development and monitoring of viral vector preparations.

Get accurate and reliable high resolution protein structure determination with cryo-EM single particle analysis techniques.