Direct determination of particle morphology is a critical aspect of nanoparticle characterization. Typical analyses include particle size distribution, shape, and overall appearance of particles in a sample. Of particular importance is lamellarity analysis. Lamellarity is the number of lipid bilayers in a liposome or lipid nanoparticle (LNP). Lamellarity directly affects liposome properties and behavior for example determining encapsulation efficiency and influencing drug release. Therefore, proper characterization of particle morphology and lamellarity is crucial to understand the potential impact on bioactivity.
Our experts have many years’ experience using TEM-based methods, particularly cryo-EM, for analyzing particle morphology and lamellarity.
Our automated methods provide reliable high-throughput image acquisition and help answer questions on size, shape, lamellarity, cargo load, and surface morphology.
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