Analyses

Particle Morphology & Lamellarity

NIS Protein Structure
NIS Molecule
NIS Protein Structure

Direct determination of particle morphology is a critical aspect of characterization.  Typical analyses include size distribution, shape, and overall appearance of particles in a sample. Of particular importance is lamellarity analysis. Lamellarity is the number of lipid bilayers in a liposome. Lamellarity directly affects liposome properties and behavior for example determining encapsulation efficiency and influencing drug release. Therefore, proper characterization of particle morphology and lamellarity is crucial to understand the potential impact on bioactivity. 

Our experts have many years’ experience using TEM-based methods, particularly cryo-EM, for analyzing particle morphology and lamellarity.

Our automated methods provide reliable high-throughput image acquisition and help answer questions on size, shape, lamellarity, cargo load, and surface morphology.

Samples We've Imaged

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Samples We've Characterized

Exosomes
Extracellular Vesicles
Iron nanoparticles
Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
Liposomes
Micelles
Nanotubes
Polymeric nanoparticles
Protein (subunit) based nanoparticles
Virus-Like Particles (VLPs)
Viruses, attenuated and recombinant (BSL-2 & below)
NIS Mountain Hero
NIS Mountain Hero