Direct determination of particle morphology is a critical aspect of nanoparticle characterization. Typical analyses include particle size distribution, shape, and overall appearance of particles in a sample. Of particular importance is lamellarity analysis. Lamellarity is the number of lipid bilayers in a liposome or lipid nanoparticle (LNP). Cryo-TEM can also visualize things like bleb formations in your lipid nanoparticle (LNP). Lamellarity directly affects liposome properties and behavior for example determining encapsulation efficiency and influencing drug release. Therefore, proper characterization of nanoparticle morphology and lamellarity is crucial to understand the potential impact on bioactivity.
- Virus-Like Particles (VLPs)
- Associated Adeno-Virus (AAV) Characterization
- Hepatitis B Virus (HBV ) Characterization
- Human Papillomavirus (HPV) Characterization
- Lentivirus Characterization
Frequently Asked Questions
Can I see an example report showing your morphology & lamellarity analysis?
How many particles do you count, or images do you analyze per sample or grid?
We collect ~60 images from different sections of each grid, usually including different ice thicknesses, and analyze the agreed upon number of particles (between 250 to over 1,000).