Leading the Revolution: CryoEM Services for Drug Discovery

We are the premier industry provider of cryoEM services, microscope access and training in electron microscopy for pharmaceutical and biotechnology companies.  In recent years, technical advancements in the cryoEM workflow have enabled high resolution structure determination of macromolecules at resolutions previously restricted to X-ray crystallography, NMR and complementary methods. This has opened up whole families of new and important targets previously thought intractable for Structure-Guided Drug Design. 

Our mission is to bring the power of CryoEM to every developer of new therapeutics through a differentiated service offering, making the method accessible and affordable for Discovery teams at all stages of method adoption. Our laboratories are powered by five of the industry's most advanced microscopes, and the industry's most experienced team of microscopists, analysts, and support staff. All of our work is performed with the quality controls and service levels expected of a top tier contract research organization.  

2,000 +

Projects Completed

200 +

Single Particle Projects

65 +

Structures better than 3.5Å

40 +

MicroED Samples Collected

CryoEM Consultation


Krios Reservations


CryoEM Starter eBook


New Programs for Structural Biology

At NIS, we recognize that adopting a new method requires access to infrastructure and expertise along with flexibility and careful budget planning. With these requirements in mind, we're excited to announce our newest enabling programs for industrial structural biologists. Whether you have a single, high value target or are looking for a deeper exploration of Glacios applications, our Starter Bundles make kicking off a new program easier than ever. New for January 2021, chameleon sample preparation in all Starter Programs.

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Structural Biology
& Chemistry

Comprehensive cryoEM & microED services for high resolution 3D structure determination.

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Biologics & Drug

TEM analysis for antibody development, gene & drug delivery, vaccine & virus characterization.

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​With Us

Learn about our unique service portfolio, including project-specific proposals, training programs & instrument access.

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Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist


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Contact us to find out how implementing TEM can help you overcome your drug discovery challenges.

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