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NanoImaging Services harnesses the power of cryo-EM to help pharma and biotech companies discover and develop novel therapeutics faster than ever before.

Harness the Power of Cryo-EM with our Core Services

3D protein structure reconstruction of hERG protein from cryo-EM imaging and analysis | structural biology | Nano Imaging Services
Scientific rendering of Liposome from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services
High resolution 3D model of trimer determined by cryo-EM imaging and analysis | structural biology | Nano Imaging Services
3D reconstruction of Human papillomavirus (HPV) virus like particle (VLP) from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services

Case Studies | NIS In Action

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Heliyon | scientific publication of Cell journalHeliyon | scientific publication of Cell journal

Janssen Research Uses an Integrative Structural Biology Approach to Generate Five Distinct Structures

A team from Janssen Research used an integrative structural biology approach to study human malic enzyme 3 (ME3), a potential therapeutic target for pancreatic cancer.

Janssen Research & Development, LLC
3210 Merryfield Row, San Diego, CA 92121
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Anellovirus Structure Reveals a Mechanism for Immune Evasion

Cryo-EM data were collected at NanoImaging Services under the leadership of Dr. Giovanna Scapin and Dr. Phat Dip. Baculovirus was generated by Dr. Peter Pushko at Medigen.

Ring Therapeutics
Ring Therapeutics, 620 Memorial Drive Suite 300, Cambridge, MA 02139, USA
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Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy

“Cryo-transmission electron microscopy was performed by NanoImaging Services, Inc…. Formulation morphology of the three lead candidate adjuvant formulations was assessed by cryo-transmission electron microscopy and compared to the morphology of a new batch of the proof-of-concept formulation manufactured at the same time as the lead candidate compositions.”

Division of Infectious Diseases and International Health
Department of Medicine, University of Virginia Charlottesville, United States
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Structural Arrangement of VH and VL Domains in COBRA™ T-cell Engaging Single-Chain Diabody

“We analyzed the structure of an epidermal growth factor receptor (EGFR) COBRA in solution using negative stain electron microscopy (EM) and small-angle X-ray scattering (SAXS)...To understand the structure of EGFR COBRA, we applied negative stain EM followed by single particle analysis that allowed us to visualize domains in this molecule at low resolution.

…[Grids of EGFR COBRA were prepared and] imaging was done by NanoImaging Services (San Diego, CA).”

Senior Scientist at Maverick Therapeutics
"Maverick Therapeutics, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Brisbane, CA, USA"
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Sugar Phosphate Activation of the Stress Sensor eIF2B

“In this work, we conduct two orthogonal unbiased screens for potential metabolite ligands of eIF2B, identifying sugar phosphates as eIF2Bα binders and enzymatic activators. Using cryo-EM and X-ray crystallography, we elucidate structures of sugar phosphates bound to eIF2B and demonstrate that they occupy the ancestral catalytic pocket within the eIF2Bα subunit…

We thank…NanoImaging Services for assistance with cryo-EM data collection and processing.”

Calico Life Sciences LLC, South San Francisco, CA, USA
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Cryo-EM in Mechanism of Action Studies: Epitope Mapping of Monoclonal Antibodies

“...we report the cryo-electron microscopy structures of potent and inhibitory anti-hArg antibodies bound to hArg1 which form distinct macromolecular complexes that are greater than 650 kDa…With local resolutions of 3.5 Å or better we unambiguously mapped epitopes and paratopes for all five antibodies and determined that the antibodies act through orthosteric and allosteric mechanisms. ….Grids were prepared and data were collected at NanoImaging Services (San Diego, CA).”

Department of Discovery Chemistry
Merck & Co., Inc., Boston, MA, USA
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Absolute Configuration Determination of Pharmaceutical Crystalline Powders by MicroED Via Chiral Salt Formation

“With moderate sample preparation, rapid data processing, and most importantly, unambiguous result interpretation, this [MicroED] approach can serve as a powerful tool in a pharmaceutical scientist's toolbox to determine the absolute configuration of a new API early in drug development, to ensure the quality of drug products, and ultimately, to improve the quality of life of patients.”

Department of Discovery Chemistry
Small Molecule Drug Product Development, Biogen, 115 Broadway, Cambridge, MA 02142, USA
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NIS Achievements | Our Impact on Drug Discovery and More



3D structures determined by cryo-EM



of protein structures solved at 3.5 Å or better resolution



phasing success rate in MicroED



Virus and VLP samples imaged



Membrane proteins solved



AAV samples imaged; 3D structure of AAV solved to 1.8 Å



Liposomal samples imaged, including LNP, EV, and OMV projects

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