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Structural analysis of membrane proteins is often challenging due to low protein yields and their unstable nature. HiTehA is particularly challenging due to its encapsulation in detergent micelles, which obstructs proper alignment of projections needed for 3D structure reconstruction.

Using cryo-EM structures, researchers propose an activation mechanism for NLRP3.

rNDV can be effectively captured and purified from clarified cell culture without a load conditioning step and that the CIMmultus QA column is not sensitive to typical cell culture pH and conductivity variations within the investigated conditions (pH 7–8; conductivity: 5–17 mS/cm).

Cryo-TEM imaging can be a powerful tool for determining the structure of antibody antigen complexes, such as those in SARS-CoV-2 Beta B.1.351.