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NanoImaging Services harnesses the power of cryo-EM to help pharma and biotech companies discover and develop novel therapeutics faster than ever before.

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Technology

Harness the Power of Cryo-EM with our Core Services

3D protein structure reconstruction of hERG protein from cryo-EM imaging and analysis | structural biology | Nano Imaging Services
Scientific rendering of Liposome from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services
High resolution 3D model of trimer determined by cryo-EM imaging and analysis | structural biology | Nano Imaging Services
3D reconstruction of Human papillomavirus (HPV) virus like particle (VLP) from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services
Structural Biology 02
Structural Biology
Gene-to-Structure 02
Protein Production
Nanoparticle Characterization 02
Nanoparticle Characterization
GMP Characterization 02
Method Validation

Publications

NIS's cryo-EM services in action
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Structure of anellovirus-like particles reveal a mechanism for immune evasion

August 22, 2024
Anelloviruses are the principal constituent of the commensal human virome. However, their structure and features were not well studied and remain elusive.
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Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

August 16, 2024
Read the latest research collaboration between Calico Life Sciences, AbbVie, C4 Therapeutics, and NIS, solving phosphatase structures supported by cryo-EM data collection.
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Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization

August 6, 2024
This research focused on developing a peptoid-based nanoparticle platform, termed "Nutshells", for the delivery of therapeutic mRNA.
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High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy

April 20, 2024
Structural analysis of membrane proteins is often challenging due to low protein yields and their unstable nature. HiTehA is particularly challenging due to its encapsulation in detergent micelles, which obstructs proper alignment of projections needed for 3D structure reconstruction.
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Structural basis for the oligomerization-facilitated NLRP3 activation

February 7, 2024
Using cryo-EM structures, researchers propose an activation mechanism for NLRP3.
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Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

February 28, 2023
Cryo-TEM imaging can be a powerful tool for determining the structure of antibody antigen complexes, such as those in SARS-CoV-2 Beta B.1.351.
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NIS Achievements | Our Impact on Drug Discovery and More

200

+

3D structures determined by cryo-EM

76

%

of protein structures solved at 3.5 Å or better resolution

70

+

Membrane proteins solved

220

+

AAV samples imaged; 3D structure of AAV solved to 1.8 Å

3,700

+

Liposomal samples imaged, including LNP, EV, and OMV projects

2,900

+

Virus and VLP samples imaged

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Upcoming Conferences & Events

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Events
April 23, 2025
Upcoming
Apr 23, 2025
Apr 24, 2025

Festival of Biologics

San Diego, CA
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