Let Our Cryo-EM
Experts Guide You

We are a US based CRO with in-house microscopes, offering protein production and cryo-EM services to support both structure-based drug design and nanoparticle characterization.

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Experts

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Technology

Harness the Power of Cryo-EM with our Core Services

3D protein structure reconstruction of hERG protein from cryo-EM imaging and analysis | structural biology | Nano Imaging Services

Scientific rendering of Liposome from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services

High resolution 3D model of trimer determined by cryo-EM imaging and analysis | structural biology | Nano Imaging Services

3D reconstruction of Human papillomavirus (HPV) virus like particle (VLP) from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services

Protein Production

Structural Biology

Nanoparticle Characterization

Method Validation

Publications

NIS's cryo-EM services in action

Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis

March 13, 2026

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Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation

October 3, 2025

NIS collaborated with scientists from Frontier Medicines to conduct structural validation of DCAF2.

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The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor

September 8, 2025

Read the latest in development of a potent and selective Polθ inhibitor, laying the groundwork for combination strategies to treat HR-deficient cancers from NIS, Repare Therapeutics, Lunenfeld-Tanenbaum Research Institute, Paraza Pharma Inc, Piramal Pharma Ltd, and Sloan Kettering Institute.

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Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity

August 1, 2025

Read about novel Sec61 inhibitor structures solved with cryo-EM in a recent publication from Kezar Life Sciences, the University of Helsinki, UCB, and the University of California, San Francisco.

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Characterization of VSV-GP morphology by cryo-EM imaging and SEC-MALS

February 6, 2025

See how cryo-TEM can provide comprehesive characterization of vesicular stomatitis virus (VSV) expressing the glycoprotein of the lymphocytic choriomeningitis virus in a recent publication from Boehringer Ingelheim Pharmaceuticals.

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