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NanoImaging Services harnesses the power of cryo-EM to help pharma and biotech companies discover and develop novel therapeutics faster than ever before.

Harness the Power of Cryo-EM with our Core Services

3D protein structure reconstruction of hERG protein from cryo-EM imaging and analysis | structural biology | Nano Imaging Services
Scientific rendering of Liposome from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services
High resolution 3D model of trimer determined by cryo-EM imaging and analysis | structural biology | Nano Imaging Services
3D reconstruction of Human papillomavirus (HPV) virus like particle (VLP) from cryo-TEM imaging and analysis | nanoparticle characterization | Nano Imaging Services

Publications

NIS's cryo-EM services in action
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High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy

April 20, 2024
Structural analysis of membrane proteins is often challenging due to low protein yields and their unstable nature. HiTehA is particularly challenging due to its encapsulation in detergent micelles, which obstructs proper alignment of projections needed for 3D structure reconstruction.
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Structural basis for the oligomerization-facilitated NLRP3 activation

February 7, 2024
Using cryo-EM structures, researchers propose an activation mechanism for NLRP3.
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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

October 21, 2023
rNDV can be effectively captured and purified from clarified cell culture without a load conditioning step and that the CIMmultus QA column is not sensitive to typical cell culture pH and conductivity variations within the investigated conditions (pH 7–8; conductivity: 5–17 mS/cm).
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Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

February 28, 2023
Cryo-EM imaging can be a powerful tool for determining the structure of antibody antigen complexes, such as those in SARS-CoV-2 Beta B.1.351.
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NIS Molecule

NIS Achievements | Our Impact on Drug Discovery and More

200

+

3D structures determined by cryo-EM

76

%

of protein structures solved at 3.5 Å or better resolution

70

+

Membrane proteins solved

220

+

AAV samples imaged; 3D structure of AAV solved to 1.8 Å

3,700

+

Liposomal samples imaged, including LNP, EV, and OMV projects

2,900

+

Virus and VLP samples imaged

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