Applications

Cryo-EM allows the determination of 3D protein structures that can be challenging to solve with other methods. NIS has developed many, flexible ways to work with clients at all stages of drug discovery.

SBDD relies on the ability to reveal 3D structures of complex proteins. Cryo-EM can provide insights into a protein's function, its role in disease, and how drug candidates bind and interact with a target.

Microcrystal electron diffraction (MicroED) provides high resolution structures for challenging small molecule samples, especially when growing large crystals is challenging.

TEM can be leveraged to provide 3D reconstructions of vaccine particles as well as to visualize structural characteristics of particles in a sample, such as homogeneity, size, distribution, purity and aggregation state.

Imagine gaining a more thorough understanding of the structural characteristics of formulations earlier in development. Optimizing nanoparticles and gene delivery vehicles with this insight can help identify issues sooner, enabling focus on the formulations most likely to succeed.

Explore how expertly deployed transmission electron microscopy (TEM) can provide critical structural analyses for manufacturing and QC applications.

Stability of liposomes, LNPs and other nanoparticle therapeuctics is a critical quality attribute. TEM analyses supplement other routine methods, allowing direct visualization of particles to monitor changes in size, shape, lamellarity and morphology.

Need to understand the structure of nanoparticles in your formulation to optimize development? Explore how NIS can help you to deploy cryo-TEM to visualize individual particles and simultaneously provide information on size, shape, lamellarity, and encapsulation.