Analyses

2D Class Averaging

Scientific rendering of 3D protein structure, structural biology | Nano Imaging
NIS Molecule
NIS Protein Structure

The fine structural details of individual particles can be difficult to discern from raw images taken on an electron microscope. This is due to the low signal-to-noise ratio typical for imaging of radiation-sensitive biological samples. It becomes even more challenging when the particles are conformationally or compositionally heterogeneous. 

Types of Proteins We've Imaged

  • Antibacterial Targets
  • Antibacterial Targets
  • Antibody-Antigen Complexes
  • Antibody-Antigen Complexes
  • DNA & RNA Editing Enzymes
  • DNA & RNA Editing Enzymes
  • DNA Binding Proteins
  • DNA Binding Proteins
  • DNA Polymerases & DNA Repair
    • POLQ
    • BRCA
  • DNA Polymerases & DNA Repair
    • POLQ
    • BRCA
  • GPCRs
  • GPCRs
  • Icosahedral Viruses
    • Adenovirus
    • Adeno Associated Virus (AAV)
  • Icosahedral Viruses
    • Adenovirus
    • Adeno Associated Virus (AAV)
  • Inflammasome
  • Inflammasome
  • Ion Channels
  • Ion Channels
  • Macromolecular Complexes
    • Ribosome
    • Spliceosome
    • BAF
  • Macromolecular Complexes
    • Ribosome
    • Spliceosome
    • BAF
  • Membrane Proteins
  • Membrane Proteins
  • Protein Degraders
    • PROTACs
    • Molecular Glues
  • Protein Degraders
    • PROTACs
    • Molecular Glues
  • Protein-Nucleic Acid Complexes
  • Protein-Nucleic Acid Complexes
  • Proteins, with & without Ligands
  • Proteins, with & without Ligands
  • Solute Carrier Transporters (SLCs)
  • Solute Carrier Transporters (SLCs)

Samples We've Characterized

  • Protein (subunit) based nanoparticles
    • Albumin NPs (Abraxane)
    • SARS-CoV-2 subunit vaccine
  • Protein (subunit) based nanoparticles
    • Albumin NPs (Abraxane)
    • SARS-CoV-2 subunit vaccine
  • Virus-Like Particles (VLPs)
    • Associated Adeno-Virus (AAV) Characterization
    • Hepatitis B Virus (HBV ) Characterization
    • Human Papillomavirus (HPV) Characterization
    • Lentivirus Characterization
  • Virus-Like Particles (VLPs)
    • Associated Adeno-Virus (AAV) Characterization
    • Hepatitis B Virus (HBV ) Characterization
    • Human Papillomavirus (HPV) Characterization
    • Lentivirus Characterization
  • Viruses, attenuated and recombinant (BSL-2 & below)
    • Adenovirus (AV) Characterization
  • Viruses, attenuated and recombinant (BSL-2 & below)
    • Adenovirus (AV) Characterization

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