Analyses

Fraction Counting

Scientific rendering of 3D protein structure, structural biology | Nano Imaging
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Protein and lipid-based nanoparticles have been widely used in clinical applications, such as drug and gene delivery and vaccine development. Their unique physical and chemical properties at the nanoscale level have paved the way for various breakthroughs in medicine and healthcare. Characterizing the homogeneity of nanoparticles is crucial for ensuring their safety, efficacy, and performance in clinical settings.

Cryo-TEM imaging is a powerful technique used to directly visualize nanoparticles, such as liposomes and lipid nanoparticles (LNPs), viruses and virus like particles (VLPs), in their near-native state. This technique can evaluate the size, morphology, internal structure, and surface features of the nanoparticles. Therefore, cryo-TEM imaging is immensely valuable in categorizing nanoparticles based on specific properties of interest.

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Types Nanoparticles We've Imaged and Analyzed

  • Extracellular Vesicles & Exosomes
  • Extracellular Vesicles & Exosomes
  • Iron nanoparticles
  • Iron nanoparticles
  • Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
  • Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
  • Liposomes
  • Liposomes
  • Micelles
  • Micelles
  • Nanotubes
  • Nanotubes
  • Polymeric nanoparticles
  • Polymeric nanoparticles
  • Protein (subunit) based nanoparticles
    • Albumin NPs (Abraxane)
    • SARS-CoV-2 subunit vaccine
  • Protein (subunit) based nanoparticles
    • Albumin NPs (Abraxane)
    • SARS-CoV-2 subunit vaccine
  • Virus-Like Particles (VLPs)
    • Associated Adeno-Virus (AAV) Characterization
    • Hepatitis B Virus (HBV ) Characterization
    • Human Papillomavirus (HPV) Characterization
    • Lentivirus Characterization
  • Virus-Like Particles (VLPs)
    • Associated Adeno-Virus (AAV) Characterization
    • Hepatitis B Virus (HBV ) Characterization
    • Human Papillomavirus (HPV) Characterization
    • Lentivirus Characterization
  • Viruses, attenuated and recombinant (BSL-2 & below)
    • Adenovirus (AV) Characterization
  • Viruses, attenuated and recombinant (BSL-2 & below)
    • Adenovirus (AV) Characterization

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