Protein and lipid-based nanoparticles have been widely used in clinical applications, such as drug and gene delivery and vaccine development. Their unique physical and chemical properties at the nanoscale level have paved the way for various breakthroughs in medicine and healthcare. Characterizing the homogeneity of nanoparticles is crucial for ensuring their safety, efficacy, and performance in clinical settings.
Cryo-TEM imaging is a powerful technique used to directly visualize nanoparticles, such as liposomes and lipid nanoparticles (LNPs), viruses and virus like particles (VLPs), in their near-native state. This technique can evaluate the size, morphology, internal structure, and surface features of the nanoparticles. Therefore, cryo-TEM imaging is immensely valuable in categorizing nanoparticles based on specific properties of interest.
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Types Nanoparticles We've Imaged and Analyzed
Extracellular Vesicles & Exosomes
Extracellular Vesicles & Exosomes
Iron nanoparticles
Iron nanoparticles
Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
Liposomes
Liposomes
Micelles
Micelles
Nanotubes
Nanotubes
Polymeric nanoparticles
Polymeric nanoparticles
Protein (subunit) based nanoparticles
Albumin NPs (Abraxane)
SARS-CoV-2 subunit vaccine
Protein (subunit) based nanoparticles
Albumin NPs (Abraxane)
SARS-CoV-2 subunit vaccine
Virus-Like Particles (VLPs)
Associated Adeno-Virus (AAV) Characterization
Hepatitis B Virus (HBV ) Characterization
Human Papillomavirus (HPV) Characterization
Lentivirus Characterization
Virus-Like Particles (VLPs)
Associated Adeno-Virus (AAV) Characterization
Hepatitis B Virus (HBV ) Characterization
Human Papillomavirus (HPV) Characterization
Lentivirus Characterization
Viruses, attenuated and recombinant (BSL-2 & below)
Adenovirus (AV) Characterization
Viruses, attenuated and recombinant (BSL-2 & below)