Publications

NIS Mountain Hero

Our clients stay on the cutting edge of drug discovery and development by harnessing the power of cryo-EM. Here is a selection of publications that have used our TEM images over the past decade-plus.

NIS Molecule

2022

  • Wang B, Bruhn JF, et al. Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation. Chem Commun (Camb). 2022 Apr 12;58(30):4711-4714. doi: 10.1039/d2cc00221c
  • Balasubramaniam D, et al. An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif. J Lipid Res. 2022 Mar 17:100198. doi: 10.1016/j.jlr.2022.100198
  • Krakow J, et al. Structural arrangement of the VH and VL domains in the COBRA™ T-cell engaging single-chain diabody. Antib Ther. 2021 Dec 16;5(1):1-10. doi: 10.1093/abt/tbab028
  • Newman, J. A.; Iuzzolino, L.; Tan, M.; Orth, P.; Bruhn, J.; Lee, A. Y. From Powders to Single Crystals: A Crystallographer’s Toolbox for Small-Molecule Structure Determination. Mol Pharmaceut2022. doi.org/10.1021/acs.molpharmaceut.2c00020
  • Gruene, T., Clabbers, M. T. B., Luebben, J., Chin, J. M., Reithofer, M. R., Stowasser, F. & Alker, A. M. (2022). J Appl Crystallogr. doi: /10.1107/s160057672200276x

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NIS Mountain Hero