Direct Visualization of Lentivirus Formulations
Cryo-TEM or negative stain TEM imaging and analysis can provide valuable insights and assessment of CQA’s, and inform batch-to-batch variability, scale-up consistency, and process development changes in lentivirus formulations.
Quantitative & qualitative analysis (for R&D purposes or using validated methods) provide a wealth of answers using a single cryo-TEM dataset, only requiring ~50μl of sample.
Cryo-TEM Characterization of Lentiviral Vectors
Cryo-TEM imaging can be used for analysis of lentivirus characteristics, including:
- Morphology (size, shape)
- Particle uniformity
- Particle integrity
- Maturation state
- Surface protein distribution
- Presence of impurities
Cryo-electron tomography provides 3D volumes to better distinguish surface protein distribution and internal particle features.
Other Viral & VLP Formulations we can Image with Cryo or NS TEM
Frequently Asked Questions
How many particles do you count, or images do you analyze per sample or grid?
Contact Us to Get Started
