Morphology & Particle Shape Analysis

Qualitative Morphology Assessment with Cryo-TEM

Cryo-TEM provides per-particle insights into morphological characteristics of nanoparticles:

Particle shape & circularity
Quantitative particle classification, including multivesicular or multicompartmental particles
Irregular particles & unexpected results
Integrity, impurities
Level of aggregation
Formulation uniformity

Detailed Insights into Nanoparticle Morphology

Cryo-TEM images & quantitative analysis provides answers about a wide variety of morphological characteristics, in one study.

Morphology analysis is essential for optimizing formulation, ensuring safety and efficacy, and meeting regulatory standards.

‍

Schedule a Meeting

Samples We Can Perform Morphology Analysis On

microscopic black and white image of adeno-associated virus (AAV) characterization with cryo-TEM

Adeno-Associated Virus (AAV)

microscopic black and white image cryo-TEM imaging of adenovirus | nanoparticle characterization

Adenovirus

microscopic black and white image of Human Papillomavirus (HPV) Characterization by cryo-TEM | nanoimaging services NIS

Human Papillomavirus (HPV)

Iron Nanoparticle characterization by Cryo-TEM | nanoparticle characterization | nanoimaging services

Iron Nanoparticles

black and white microscopic image of of lipid nanoparticle nanoparticle LNP characterization | nanoimaging services

Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads

black and white microscopic image of doxorubicin encapsulated liposome nanoparticle characterization by cryo-TEM

Liposomes

Micelles

Services Related To Morphology Analysis

Complete Morphology Assessment with Cryo-TEM

Direct determination of particle morphology is a critical aspect of nanoparticle characterization. Typical analyses include particle size distribution, shape, and overall appearance of particles in a sample, and can include quantitative analysis of circularity.

All of these measurements can be obtained in one cryo-TEM or negative stain imaging study, with a small amount of sample.

Schedule a Meeting