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Experimental Validation in AI-Driven Drug Discovery: Where Structural Biology Fits

CryoTEM on the USP Certificate: A Milestone for AAV Capsid Characterization

Selecting an LNP Characterization Workflow

Choosing an AAV Characterization Worfklow

Characterization of LNP Payload Distribution and Loading Percentage

The Bleb Blog: A Deep Dive with Cryo-TEM

Enhancing Contrast and Adding Scale Bars to TEM Images Quickly and Easily

A Guide to Cryo-Grid Production: Materials, Interfaces, and Their Impact on Sample Prep

From Structure to Solution: How Structural Biology Informs the Development of Drugs Targeting G Protein-Coupled Receptors

From Ice Contamination to Carbon Artifacts: A Guide to Understanding & Overcoming TEM Imaging Challenges

The Ins and Outs of Epitope Mapping with Cryo-EM: How Do You Do It?

Unlocking the Secrets of RNA: Protein-Free Structure Determination with Cryo-Electron Microscopy

Seeing the Building Blocks: Direct Imaging of Payload Distribution of DNA and RNA in Lipid Nanoparticles

Epitope Mapping for Drug Discovery

Visualizing Nanomedicines: Understanding Your Nanoparticle Formulations

Unraveling the Mysteries of the Molecular World: Structural Biology Techniques

Exploring the World of Target Protein Degradation: A Look into PROTAC® Degraders and Molecular Glues

The Cutting Edge of Imaging: How Transmission Electron Microscopy Continues to Advance Research

Seeing the Forest AND the Trees: Lipid Nanoparticle Analysis with Cryo-TEM

“One View that Rules them All” and Other Vitrification Hurdles in Cryo-EM

Structure Matters: Characterization of the hERG anti-target by cryo-EM

Antibody Development - Structural Characterization of Antibodies with Cryo-EM

Negative Stain for High Resolution Cryo-EM Workflows

Overcoming Bottlenecks in Cryo-EM Enabled Drug Design

How Cryo-EM can Improve the Design of Scaffolds in Medicinal Chemistry

Cryo-EM in Gene Delivery

Imaging PROTAC Mediated Degradation Complexes with Cryo-EM

Ordered Mass in Target Selection & Protein Engineering

Solving the Challenges of Preferred Orientation in Cryo-EM Sample Preparation

High Resolution Epitope Mapping with Cryo-EM

Three Common Challenges to Adopting Cryo-EM in your Drug Discovery Program (and How to Overcome Them)

Cryo-EM: What Level of Outsourcing is Right for You?

Cryo-EM: How to Test the Waters with a Proof-of-Concept Study

Skipping Negative Stain

Comprehensive Assessment of Samples for Cryo-EM Feasibility

Resource CMS

Revealing 3D Structure of Nanoparticles with Cryo-electron Tomography

Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs

Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis

Structural Heterogeneity in Focus: Preparing for Cryo-EM Success

Gene-to-Structure Workflow for CRBN-DDB1

Protein Degraders in Focus: Preparing for Cryo-EM Success

Cryo-EM Structure of CYP3A4 Unliganded and In Complex with a Substrate

Soluble Proteins in Focus: Preparing for Cryo-EM Success

Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation

The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor

Technical Note: Cryo-TEM Characterization of Adeno-Associated Virus (AAV) Capsid Ratios

Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity

Characterization of LNP Payload Distribution and Loading Percentage

Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Automated Cryo-TEM Analysis of AAV Empty/Full Capsid Ratios

Cryo EM: Back to Basics - Chapter 3

A novel interleukin-10 antibody graft to treat inflammatory bowel disease

Cryo-EM: Back to Basics - Chapter 2

Characterization of VSV-GP morphology by cryo-EM imaging and SEC-MALS

Characterization of VSV-GP morphology by cryo-EM imaging and SEC-MALS

Cryo-EM: Back to Basics - Chapter 1

The Cryo-EM structure of human serum albumin in complex with ligands

Structure of anellovirus-like particles reveal a mechanism for immune evasion

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Cryo-EM in Focus: Transforming the Landscape of Membrane Protein Research

Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization

High-Resolution Structure Determination of Small Proteins by Cryo-EM Using a Glacios Microscope

High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy

Seeing Through the Fog: Using Cryo-TEM to Characterize LNPs During Formulation and Process Changes

Seeing Through the Fog: Cryo-TEM as a Powerful Analytical Tool for LNP Characterization During Development & Manufacturing

Structural basis for the oligomerization-facilitated NLRP3 activation

Cryo-TEM Analysis of LNPs Across Mixing Systems, including Bleb Structure Formation

SPT Labtech and NIS at Microscopy & Microanalysis 2022

Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Cryo-EM for Epitope Mapping

The Glycerol Dilemma: the Tradeoff between Stability and Contrast in Cryo-EM

Purification of a recombinant oncolytic virus from clarified cell culture media by anion exchange monolith chromatography

Stressed stability and protective efficacy of lead lyophilized formulations of ID93+GLA-SE tuberculosis vaccine

Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

Absolute Configuration Determination of Chiral API Molecules by MicroED Analysis of Cocrystal Powders Formed Based on Cocrystal Propensity Prediction Calculations

The Resolution Revolution

Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer

How VLP Structural Insights from Cryo-TEM Helped Characterize the GARDASIL® Vaccine

Quality Control of AAV Production with Cryo-TEM

Absolute configuration determination of SMTP-7 via microcrystal electron diffraction (MicroED)

Harness the Power of Cryo-EM

Nanoparticle Characterization Tips

Anellovirus Structure Reveals a Mechanism for Immune Evasion

IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2

CELLOPT: improved unit-cell parameters for electron diffraction data of small-molecule crystals

From Powders to Single Crystals: A Crystallographer's Toolbox for Small-Molecule Structure Determination

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2

Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation

Structural arrangement of the VH and VL domains in the COBRA T-cell engaging single-chain diabody

Routine collection of 10,000 direct detector movies a day using Leginon

Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

Small Molecule Microcrystal Electron Diffraction for the Pharmaceutical Industry Lessons Learned From Examining Over Fifty Samples

Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy

Sugar phosphate activation of the stress sensor eIF2B

Real-Time Cryo-Electron Microscopy Analysis with cryoSPARC

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Cryo-EM: Perspectives of an Industrial Crystallographer

Electron Microscopy in Virus Structural Biology and Vaccine Development

Events CMS

NESBA Cryo-EM Symposium

AAPS 2025 PharmSci 360

Degraders in Focus: Preparing for Cryo-EM Success

8th Annual TPD & Induced Proximity Summit

7th Gene Therapy Analytical Development Summit

Soluble Proteins in Focus: Preparing for Cryo-EM Success

Discovery on Target

GPCR Happy Hour

Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Sanofi Global Analytical Symposium 2025

ASGCT 28th Annual Meeting

Quantitative Empty/Full Analysis of AAV Capsids Using Cryo-TEM

Industrial Biostructures America 2025

Festival of Biologics

4th LNP Formulation & Process Development Summit

Cryo-EM: Back to Basics - Part 3: Overcoming Limitations

Unique Capabilities of Cryo-EM in Structure Determination and its Potential in Drug Discovery | Webinar

Cryo-EM: Back to Basics - Part 2: Data Processing & Interpretation

WCBP Symposium 2025

Cryo-EM: Back to Basics - Part 1: Sample Prep & Imaging

Eastern Analytical Symposium & Exposition 2024

PSDI (Protein Structure Determination in Industry) 2024

6th Gene Therapy Analytical Development & CMC Summit

7th Annual Targeted Protein Degradation (TPD)

SoCal Cryo-EM Symposium 2024

NESBA Cryo-EM Mini Symposium

6th Exosome Based Therapeutic Summit

3rd Next Generation Lipid-Based Nanoparticles Delivery Summit

4th Annual mRNA-Based Therapeutics Summit

High-Resolution Structure Determination of Small Proteins by Cryo-EM Using a Glacios Microscope

74th ACA Annual Meeting

Structure-Based Drug Design Summit 2024

Cryo-EM Open House

20th Annual PEGS Boston Summit

2024 AAPS National Biotechnology Conference

3rd LNP Formulation & Process Development Summit

19th Annual Drug Discovery Chemistry

3rd GPCRs-Targeted Drug Discovery Summit

3rd mRNA Analytical Development Summit

Cryo-TEM Analysis of LNPs Across Mixing Systems, including Bleb Structure Formation

WCBP Symposium 2024

5th Annual Gene Therapy Analytical Development Summit

31st Protein Structure Determination in Industry Meeting (PSDI)

6th Annual Targeted Protein Degradation

8th Annual 2023 SoCal Cryo-EM Symposium

Cryo-EM for Epitope Mapping

NIS & TFS Cryo-EM Open House and Networking

5th Exosome Based Therapeutic Summit

Cryo-EM: Transforming Drug Discovery Paradigms Symposium

2nd Next Generation Lipid-Based Nanoparticles Delivery Summit

3rd Annual mRNA-Based Therapeutics Summit

3rd Induced proximity-Based Drug Discovery Summit 2023

2023 American Crystallographic Society (ACA) Annual Meeting

American Society for Virology 2023

International School of Crystallography 2023

19th Annual PEGS Boston Summit

9th NovAliX Conference Biophysics in Drug Discovery

ThermoFisher Scientific & NIS Open House

2nd LNP Formulation & Process Development Summit

2023 Ligase Targeting Drug Development Summit

4th Annual Protein Degradation & Targeting Undruggables Summit

2nd GPCR-Targeted Drug Discovery Summit

2nd mRNA Analytical Development Summit

Molecular Glue Drug Development Summit

WCBP Symposium 2023

NESBA Cryo-EM Mini-Symposium, January 2023

Gene Therapy Analytical Development Summit 2022

5th Annual Targeted Protein Degredation

30th Protein Structure Determination in Industry

4th Extracellular Vesicle-Based Therapeutic Development Summit

Taking the plunge: Getting results using Cryo-EM Open House

America Drug Delivery and Formulation Summit

Discngine Labs: The future of Cryo-EM in Pharma

Microscopy & Microanalysis 2022

America Drug Delivery and Formulation Summit

Next Generation Lipid-Based Nanoparticles Delivery Summit

25th International Conference on the Chemistry of the Organic Solid State

COMPPÅ Symposium on Membrane Protein Production and Analysis

Vaccine Technology VIII

PEGS Boston 2022

NIS Mountain Hero