January 28, 2026

Structural Heterogeneity in Focus: Preparing for Cryo-EM Success

Request a quote

NIS demonstrates how cryo-EM can be used for epitope mapping of structurally heterogeneous samples.

Dr. Kenny Kang, Senior Scientist at NanoImaging Services, demonstrates how cryo-EM can visualize discrete states within conformationally flexible samples, using the SARS-CoV-2 spike protein as a case study.

Structural Heterogeneity in Focus: Preparing for Cryo-EM Success

Gene-to-Structure Workflow for CRBN-DDB1

Protein Degraders in Focus: Preparing for Cryo-EM Success

Cryo-EM Structure of CYP3A4 Unliganded and In Complex with a Substrate

Soluble Proteins in Focus: Preparing for Cryo-EM Success

Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation

The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor

Technical Note: Cryo-TEM Characterization of Adeno-Associated Virus (AAV) Capsid Ratios

Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity

Characterization of LNP Payload Distribution and Loading Percentage

Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Automated Cryo-TEM Analysis of AAV Empty/Full Capsid Ratios

Cryo EM: Back to Basics - Chapter 3

A novel interleukin-10 antibody graft to treat inflammatory bowel disease

Cryo-EM: Back to Basics - Chapter 2

Characterization of VSV-GP morphology by cryo-EM imaging and SEC-MALS

Characterization of VSV-GP morphology by cryo-EM imaging and SEC-MALS

Cryo-EM: Back to Basics - Chapter 1

The Cryo-EM structure of human serum albumin in complex with ligands

Structure of anellovirus-like particles reveal a mechanism for immune evasion

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Cryo-EM in Focus: Transforming the Landscape of Membrane Protein Research

Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization

High-Resolution Structure Determination of Small Proteins by Cryo-EM Using a Glacios Microscope

High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy

Seeing Through the Fog: Using Cryo-TEM to Characterize LNPs During Formulation and Process Changes

Seeing Through the Fog: Cryo-TEM as a Powerful Analytical Tool for LNP Characterization During Development & Manufacturing

Structural basis for the oligomerization-facilitated NLRP3 activation

Cryo-TEM Analysis of LNPs Across Mixing Systems, including Bleb Structure Formation

SPT Labtech and NIS at Microscopy & Microanalysis 2022

Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Cryo-EM for Epitope Mapping

The Glycerol Dilemma: the Tradeoff between Stability and Contrast in Cryo-EM

Purification of a recombinant oncolytic virus from clarified cell culture media by anion exchange monolith chromatography

Stressed stability and protective efficacy of lead lyophilized formulations of ID93+GLA-SE tuberculosis vaccine

Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

Absolute Configuration Determination of Chiral API Molecules by MicroED Analysis of Cocrystal Powders Formed Based on Cocrystal Propensity Prediction Calculations

The Resolution Revolution

Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer

How VLP Structural Insights from Cryo-TEM Helped Characterize the GARDASIL® Vaccine

Quality Control of AAV Production with Cryo-TEM

Absolute configuration determination of SMTP-7 via microcrystal electron diffraction (MicroED)

Harness the Power of Cryo-EM

Nanoparticle Characterization Tips

Anellovirus Structure Reveals a Mechanism for Immune Evasion

IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2

CELLOPT: improved unit-cell parameters for electron diffraction data of small-molecule crystals

From Powders to Single Crystals: A Crystallographer's Toolbox for Small-Molecule Structure Determination

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2

Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation

Structural arrangement of the VH and VL domains in the COBRA T-cell engaging single-chain diabody

Routine collection of 10,000 direct detector movies a day using Leginon

Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

Small Molecule Microcrystal Electron Diffraction for the Pharmaceutical Industry Lessons Learned From Examining Over Fifty Samples

Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy

Sugar phosphate activation of the stress sensor eIF2B

Real-Time Cryo-Electron Microscopy Analysis with cryoSPARC

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Cryo-EM: Perspectives of an Industrial Crystallographer

Electron Microscopy in Virus Structural Biology and Vaccine Development

NIS Mountain Hero