March 31, 2026

Revealing 3D Structure of Nanoparticles with Cryo-electron Tomography

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NIS discusses how cryo-ET can be used to visualize the 3D architecture of complex nanoparticles.

Are your lipid nanoparticles assembling correctly? Is sample heterogeneity compromising your drug formulation? Cryo-electron tomography (cryo-ET) can answer these questions - but only if you know how to apply it effectively.

Dr. Eric Bushong, Principal Scientist at NanoImaging Services, provides a practical demonstration of how cryo-ET reveals the true 3D architecture of complex nanoparticles. You'll see real examples of LNPs and viral particles reconstructed at nanometer resolution, learn to identify structural defects that standard methods miss, and discover how 3D visualization can validate your particle design and characterize heterogeneity in your samples.

Revealing 3D Structure of Nanoparticles with Cryo-electron Tomography

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Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation

Structural arrangement of the VH and VL domains in the COBRA T-cell engaging single-chain diabody

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