Services

Nanoparticle Characterization

Nanoparticle CharacterizationNanoparticle Characterization

Therapeutic nanoparticles used in drug, vaccine, and gene therapy delivery are complex, and vary in composition, shape and size. As structure can change under stress, characterization of nanoparticles’ physicochemical properties is required to understand how they interact with their environment and can provide insight into the potential safety and efficacy of the final formulation. Size, shape, lamellarity and morphology of nanoparticles affect drug incorporation, stability, and release, which in turn affect cell toxicity, targeting and therapeutic efficacy. In addition, the study of encapsulation efficiency (full/empty liposomes or capsids) when looking at gene or drug delivery systems is crucial, as the presence of many empty particles or impurities (or non-intact capsid for VLPs) affects immunogenic response.

Cryo-TEM provides important structural details on a per-particle basis that cannot be captured by other methods, quickly visualizing individual particles in the size range of ~5-500 nm.

Imagine what you can achieve if you can gain a more thorough understanding of physical structure earlier in development. NanoImaging Services makes this possible.

Expertly-Performed Cryo-TEM Provides the
Whole Picture, Earlier

Cryo-TEM can unveil many aspects of a sample simultaneously, in a single image (for example size, drug encapsulation, shape, morphology, impurities, integrity, aggregation), all with a tiny amount of sample. This makes cryo-TEM a powerful orthogonal technique to complement your characterization toolkit. Where a sample contains multiple particle types, for example in vaccine drug products, cryo-TEM outperforms. Similarly, when a sample needs to be analyzed at a concentration similar to drug preparation for IV administration, cryo-TEM is the solution, as it can handle relatively low sample concentrations.

Access the power of cryo-TEM through NIS to get a more in-depth view earlier, fast-tracking your therapeutic development. 

We provide quick, flexible and cost-effective access to the answers cryo-TEM can reveal. Partner with the original and most experienced team in cryo-TEM and access cutting edge instruments to help accelerate your projects.

Access the power of cryo-TEM through NIS to get a more in-depth view earlier, fast-tracking your therapeutic development. 

We provide quick, flexible and cost-effective access to the answers cryo-TEM can reveal. Partner with the original and most experienced team in cryo-TEM and access cutting edge instruments to help accelerate your projects.

Nanoparticles We've Characterized

Liposomes
Iron nanoparticles
Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
Exosomes
Micelles
Polymeric nanoparticles
Virus-Like Particles (VLPs)
  • AAV
  • HBV
  • HPV
  • Lentivirus
Protein (subunit) based nanoparticles
  • Albumin NPs (Abraxane)
  • SARS-CoV-2 subunit vaccine
Viruses, attenuated and recombinant (BSL-2 & below)
Extracellular Vesicles
Nanotubes
NIS Mountain Hero