Per-Particle Imaging of Liposomes
Cryo-TEM imaging & automated analysis tools can provide insights into liposomal formulations in their near native state, with just ~50μl of sample.
Validated methods & data inform batch-to-batch, scale-up, and process development change comparisons.
Analyze Multiple Liposome CQA’s in One Dataset
Assess many characteristics of liposomes with one cryo-TEM study:
- Particle morphology
- Lamellarity, including bilayer thickness
- Uniformity
- Particle size distribution
- Estimations of PEG layer thickness
- Cargo encapsulation
- 3D volumes with cryo-electron tomography
Lipid Nanoformulations We Can Image With Cryo or NS TEM
Frequently Asked Questions
How many particles do you count, or images do you analyze per sample or grid?
How do you measure the PEG layer in liposome formulations?
What type of lipid nanoformulations do you have experience with?
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