Applications

Structure-Based Drug Design (SBDD)

NIS Molecule
NIS Protein Structure
NIS Protein Structure

Understanding how drugs interact with the proteins they are designed to target is a critical step in drug discovery. For optimum success, they must hit the right target with the expected effect to be considered safe before entering clinical trials. Structure-based drug design is the design and optimization of a chemical structure by structural biologists. They aim to identify the best compounds suitable for clinical testing, using knowledge of the candidate’s three-dimensional structure (3D structure) and how its shape and charge cause it to interact with its biological target.

Structure-based drug design relies on the ability to reveal the 3D structures of complex proteins. Cryo-electron microscopy (cryo-EM) can provide the requisite insights into:

  • A protein’s biological function
  • Its role in disease 
  • How drug candidates bind and interact

NIS helps you design and optimize the best drug candidate.

Imagine gaining a comprehensive 3D structural understanding of a drug target that’s not amenable to x-ray crystallography, without needing to be an expert in a challenging field. NanoImaging Services’ deployment of cryo-EM makes this possible. We have worked with many leading pharmaceutical and biotech companies to deploy TEM, and particularly cryo-EM, in structure-based drug design. Partnering with us has enabled structural biologists to gain the information they require to perform their role at a higher level. 

We have solved over 150 3D protein structures, half of which have been challenging membrane proteins, and over 76% of datasets from our Titan Krios are below 3.5 Å. Our services are designed flexibly to help you resolve complexity.

Samples We've Imaged

Antibody-antigen complexes
GPCRs
Ion channels
Membrane proteins
Multi-domain proteins
Multi-component complexes
Protein degraders
Protein-nucleic acid complexes
Proteins - with and without ligands

Nanoparticles We've Imaged

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