Drug Stability Testing

NIS Molecule
NIS Protein Structure
NIS Protein Structure

The thermal stability of liposomes and other nanoparticles often reflects their in vivo stability and drug release characteristics. These properties can be adversely influenced and affected by the added components, including the drug itself, making it important to understand the structure and dynamics of the system as a whole. Stability is a critical quality attribute that must be controlled during development and manufacturing, through to final product use.

TEM, and in particular, cryo-TEM allows for the direct visualization of particles and a comprehensive characterization of morphology to monitor and ensure product stability. The direct analysis capability allows for monitoring the effect of changes to the size, shape, lamellarity, morphology, from external variables such as product contamination and storage on particle stability. 

NIS helps visualize critical quality attributes directly

Imagine what you can achieve by gaining a more thorough way of monitoring and controlling critical quality attributes such as product stability during manufacturing and process control. NanoImaging Services makes this possible. Our services help navigate you to the best product fast, saving you time, money, and ultimately a better performing final product.

Samples We've Imaged

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Nanoparticles We've Imaged

Extracellular Vesicles
Iron nanoparticles
Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
Polymeric nanoparticles
Protein (subunit) based nanoparticles
Virus-Like Particles (VLPs)
Viruses, attenuated and recombinant (BSL-2 & below)
NIS Mountain Hero