Extracellular Vesicles, including Exosomes

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Analyses Related to Extracellular Vesicles & Exosomes

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Characterize Extracellular Vesicles & Exosomes with Cryo-TEM Direct Imaging

EVs/exosomes can range in size from 50 nanometers to hundreds of nanometers, depending on their type, source, and cargo. They can also vary in structure, internal cargo, and surface decoration. Unlike any other technique, cryo-TEM allows for direct visualization of each of these attributes. Size distribution analysis and particle classification studies can be used to compare lots and study stability. Immunogold labeling can be performed to confirm the presence of proteins on the surface of EVs/exosomes.

Vesi-Ref CD63 GFP EV standard (Samples provided courtesy of Vesiculab)

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Learn about Cryo-TEM Studies for Characterizing your Nanoparticles.

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Cryo-Electron Tomography (Cryo-ET)

Cryo-Electron tomography services for generating 3D volumes of heterogeneous particles, like LNPs, liposomes & complexes.

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Cryo-TEM Imaging & Analysis

Analyze critical quality attributes of your nanoparticle formulations with cryo-TEM per particle imaging & automated analysis.

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Lamellarity & Blebbing Analysis

Cryo-TEM imaging can be used to visualize lamellarity, including blebbing, to provide important structural information.

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Method Validation

Method validation services to analyze critical quality attributes for regulatory submissions.

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Morphology & Particle Shape Analysis

Complete morphology assessment, including shape & circularity, of nanoparticle formulations.

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Negative Stain TEM Imaging

Visualize gross structural features of individual particles with rapid negative stain transmission electron imaging.

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Automated Particle Classification Analysis

Quantitative, automated analysis of VLP, virus, LNP, & liposome formulation characteristics like morphology, payload & lamellarity with cryo-TEM imaging.

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Particle Size Distribution Analysis

Automated particle size distribution measurements using cryo-TEM & nsTEM imaging, including distribution curves, mean AED, mean/max Feret.

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Payload Distribution & Encapsulation Efficiency Analysis

Quantitative gene & drug payload distribution in formulations including VLPs, LNPs, & liposomes with cryo-TEM imaging & automated analysis.

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Formulation Stability Studies

Comprehensive stability analytical services of drug product & formulations with cryo-TEM imaging & automated assessment of size, morphology & payload.

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