Lipid Nanoformulations

NIS Molecule

Cryo-TEM illuminates lipid nanoformulation characteristics including particle heterogeneity, size, morphology, lamellarity, and cargo encapsulation which are key for successful nanoparticle development, formulation, and manufacturing. 

Direct imaging paired with quantitative & qualitative analysis of critical quality attributes (CQAs) can accelerate lipid and LNP based vaccines & therapeutics. These values can be used to inform batch-to-batch, scale-up, and process development change comparisons.

3,700+ Liposomal Samples Imaged

With over 3,700 liposomal samples imaged at NIS, we are highly experienced with lipid nanoparticles (LNPs), liposomes, and micelles. 

Cryo-TEM imaging can provide quantitative & qualitative information about lipid formulations including:

  • Uniformity
  • Lamellarity
  • Particle size distribution
  • Payload distribution
  • Shape and overall morphology
  • Impurities present in the sample
  • PEG layer thickness

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Learn about Cryo-TEM Studies for Characterizing your Nanoparticles.

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Frequently Asked Questions

microscopic black and white image of liposome analysis | Lipid Nanoformulation Analysis Services

What type of lipid nanoformulations do you have experience with?

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