Identifying and developing molecules with optimal properties against a validated target is fundamental in pharmaceutical research. Knowledge of the target’s three-dimensional structure may accelerate such development. Structural biologists require a range of techniques to interrogate both small and large molecules in three dimensions. Cryo-EM is an aspirational structural technique for many, but cost, infrastructure and skills often prevent its adoption.
NanoImaging Services provides quick and easy access to the answers that cryo-EM can reveal. Partner with the original and most experienced Cryo-EM CRO (contract research organization) to access expertise and cutting edge instruments to fast track your projects.
Cryo-EM is perfect for analyzing small molecules binding to biological entities including DNA, RNA, proteins, carbohydrates, and lipids. Using our structural biology service, structure scientists can easily answer medicinal chemists’ questions regarding the chosen target structure and function to help design and optimize candidates that would interact with it.
Increasingly, structural biologists partner with NIS to investigate protein-protein complexes, such as how monoclonal antibodies (MAbs) bind to their target. Using cryo-EM, we provide the structural information required to guide the modification of the structure of MAbs to generate highly specific and effective antibodies with optimized processing, stability, and tolerance.
Making cryo-EM accessible means building flexible models for working with companies of all stages and sizes. NanoImaging Services offers a range of options across the development spectrum.