Services

Small Molecule MicroED

Small Molecule MicroEDSmall Molecule MicroED

Microcrystal electron diffraction (MicroED) is a structural technique that leverages the strong interactions of matter with electrons. MicroED services determine high-resolution structures from very thin micro- and nanocrystals. A transmission electron microscope is used to collect diffraction data, which is processed by standard crystallographic programs, allowing for rapid structure determination

Our MicroED workflow provides high resolution structures for challenging small molecule samples. It is particularly suited to studies when starting material is extremely limited or when growing large crystals for X-ray crystallography is challenging. With MicroED, crystals that are orders of magnitude smaller than those needed for X-ray crystallography can be used to yield high quality data. 

Small Molecule Studies From the Cryo-EM Experts

We have developed robust commercial MicroED services for small molecule studies to support a variety of industrial chemistry workflows. As one of the first providers of MicroED services, we have collected data from over 100 samples and solved more than 50 unique structures internally. Our structures have cleared up structure ambiguities, assigned absolute configuration, identified unwanted synthetic byproducts and guided polymorph selection for solid formulations. Solving a crystal structure early in the drug development process can expedite IND/NDA filing and ultimately strengthen your intellectual property.

Small Molecule Studies From the Cryo-EM Experts

We have developed robust commercial MicroED services for small molecule studies to support a variety of industrial chemistry workflows. As one of the first providers of MicroED services, we have collected data from over 100 samples and solved more than 50 unique structures internally. Our structures have cleared up structure ambiguities, assigned absolute configuration, identified unwanted synthetic byproducts and guided polymorph selection for solid formulations. Solving a crystal structure early in the drug development process can expedite IND/NDA filing and ultimately strengthen your intellectual property.

Leave it to us to go from sample to structure with a fast turnaround. Our experienced team can screen for diffracting crystals using X-ray powder diffraction (PXRD), collect MicroED data with our in-house developed automation software , process data on the fly and provide a fully refined structural model. Our team of expert crystallographers are able to tackle even the most challenging crystals and are staying abreast of this rapidly advancing field.

Nanoparticles We've Characterized

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