Publications

Janssen Research Uses an Integrative Structural Biology Approach to Generate Five Distinct Structures

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A team from Janssen Research used an integrative structural biology approach to study human malic enzyme 3 (ME3), a potential therapeutic target for pancreatic cancer.

A team from Janssen Research used an integrative structural biology approach to study human malic enzyme 3 (ME3), a potential therapeutic target for pancreatic cancers. Through a combination of crystallography and Cryo-EM, the team generated five distinct structures which improve our understanding of the conformation dynamics, flexibility, and potential regulation of the enzyme. ME3 proves to be a non-allosterically regulated enzyme with a highly flexible loop AB suggesting a distinct regulatory and functional role from other enzymes in the same family. The additional structural information may help to explain the specificity of therapeutics targeting malic enzymes and enable structure based drug design for ME3.

Case Studies: NIS in Action

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CryoTEM in Preclinical Vaccine Development: Characterizing the lead candidate adjuvant formulation

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Negative Staining Electron Microscopy: Unfolding the structural arrangement of domains in single chain diabody

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Ring Therapeutics solved the first Anellovirus structure by using cryo-EM.

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Merck Used cryo-EM to Gain Insight Into Mechanism of Action by Imaging Structures of Inhibitory Antibodies Complexed with Arginase 1.

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Determine the Absolute Configuration of a New API Early in Drug Development with MicroED.

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Cryo-EM in Ligand Binding Site Studies: Sugar phosphate activation of the stress sensor eIF2B.

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