Protein structure determination services
View protein structures at near-atomic resolutions and rapidly expand your structure-based drug target programs via our robust and flexible cryoEM-based workflows.
Overcome the limitations of traditional approaches
Understanding the relationship between structure and function for high-value drug targets can provide critical data that ultimately reduces the time and cost investment required to bring a new drug to the clinic.
Those looking to adopt a structure-based approach to drug discovery however face several challenges, including:
- Traditional structure-determination approaches require comparatively large quantities of pure, stable material
- Many large and/or dynamic proteins are not amenable to crystallization
- Unique conformational states may not be tractable in crystal systems not be tractable in crystal systems
Single-particle analysis via cryoEM is fast becoming a standard and critical technique for structure-based drug design
- These are both available for general user access and allow our customers to generate thousands of images daily
- More than 70% of structures determined from Krios-generated data achieve resolutions better than 3.5A
- Installed across our locations to allow for local sample screening, preparation and analysis
- A high-speed network will connect our facilities and the Krios microscopes for high-resolution data acquisition
- Integral membrane proteins (including ion channels, transporters, and GPCRs)
- Large protein complexes
- Molecular machines & dynamic systems
- Gene editors
Our services have been designed to support a full range of projects from early proof-of-concept studies to long term sustainable access to instrumentation and FTE resource, allowing our pharma and biotech clients to rapidly expand their SBDD target enablement programs.
Contact us to get started
At NIS, we’ve created a complete network of resources and a range of services to meet our customers’ specific needs. Contact us today to see how we can help you with your program.
- Han, Y., Reyes, A. A., Malik, S., & He, Y. (2020). Cryo-EM structure of SWI/SNF complex bound to a nucleosome. Nature, 579(7799), 452–455. https://doi.org/10.1038/s41586-020-2087-1
- Kumar, P., Wang, Y., Zhang, Z., Zhao, Z., Cymes, G. D., Tajkhorshid, E., & Grosman, C. (2020). Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine only bilayer. Proceedings of the National Academy of Sciences of the United States of America, 117(3), 1788–1798. https://doi.org/10.1073/pnas.1906823117
- Kobayashi, K., Shihoya, W., Nishizawa, T., Kadji, F. M. N., Aoki, J., Inoue, A., & Nureki, O. (2020). Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nature, 27(3), 274–280. https://doi.org/10.1038/s41594-020-0386-8