Analyses

Particle Size Distribution Analysis

Scientific rendering of 3D protein structure, structural biology | Nano Imaging
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NIS Protein Structure

Assessment of the size distribution for particles in a given sample is an essential characterization step in pharmaceutical and biotechnology process validation & development, formulation development, and production. Particle size distribution is directly linked to many other product attributes and can affect their performance. 

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Samples We've Characterized

  • Extracellular Vesicles & Exosomes
  • Extracellular Vesicles & Exosomes
  • Iron Nanoparticles
  • Iron Nanoparticles
  • Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
  • Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
  • Liposomes
  • Liposomes
  • Micelles
  • Micelles
  • Nanotubes
  • Nanotubes
  • Polymeric nanoparticles
  • Polymeric nanoparticles
  • Protein based nanoparticles
    • Albumin NPs (Abraxane)
    • SARS-CoV-2 subunit vaccine
  • Protein based nanoparticles
    • Albumin NPs (Abraxane)
    • SARS-CoV-2 subunit vaccine
  • Virus-Like Particles (VLPs)
    • Associated Adeno-Virus (AAV) Characterization
    • Hepatitis B Virus (HBV ) Characterization
    • Human Papillomavirus (HPV) Characterization
    • Lentivirus Characterization
  • Virus-Like Particles (VLPs)
    • Associated Adeno-Virus (AAV) Characterization
    • Hepatitis B Virus (HBV ) Characterization
    • Human Papillomavirus (HPV) Characterization
    • Lentivirus Characterization
  • Viruses, attenuated and recombinant (BSL-2 & below)
    • Adenovirus (AV) Characterization
  • Viruses, attenuated and recombinant (BSL-2 & below)
    • Adenovirus (AV) Characterization

Frequently Asked Questions

Explore how our experts can help you.

NIS Molecule

Can I see an example report for particle size distribution?

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Yes! Please contact us to get an example report showing services including lipid nanoparticle (LNP) cryo-TEM imaging at three magnifications along with our Qualitative Assessment, Particle Size Distribution, and Fraction Counting Analysis.

How many particles do you count, or images do you analyze per sample or grid?

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We collect ~60 images from different sections of each grid, usually including different ice thicknesses, and analyze the agreed upon number of particles (between 250 to over 1,000).

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