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NanoImaging Services provides transmission electron microscopy imaging and analysis of samples in solution preserved either in negative stain or vitreous ice (cryo preservation).
Preview services provide a small sample of images for preliminary assessment.
Automated data collection services provide a statistical sampling of the specimen.
Analysis services include particle characterization and single particle reconstruction.
Please contact us to discuss your project requirements in more detail. |
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Gardasil® Characterization Project -- an Example |
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Clint Potter and Bridget Carragher, cofounders of NanoImaging Services, have established several research collaborations with pharmaceutical companies aimed at developing new methods to characterize biopharmaceuticals using cryoTEM. Working on the Gardasil® characterization project for Merck & Co., Potter and Carragher developed advances in specimen preparation, in microscope control and automation, and in data tracking.
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| CryoTEM image of human papillomavirus virus-like particles,
Courtesy of Merck & Co., Inc. and the National Resource for Automated
Molecular Microscopy, The Scripps Research Institute. |
Three dimensional reconstruction of Fab binding on human
papillomavirus virus-like particles, Courtesy of Merck & Co., Inc.
and the National Resource for Automated Molecular Microscopy, The
Scripps Research Institute. |
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Digital imaging
High-resolution TEM digital images, extensive calibration of data collection parameters and automated procedures for statistically sampling specimen grid.
Integrated database
Complete record of all specimen preparation, data collection and data analysis parameters.
More than just a stack of micrographs
Annotated results and a final summary and report of every imaging experiment for each specimen.
Instant access
All images, associated parameters and data accessed instantly on a web browser over a secure connection.
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