NanoImaging--Template

3D Structure

Three dimensional reconstruction imaging of nanoscale structures using tomography or single particle averaging (SPA) methods.

Electron Tomography
in silico 3D reconstruction using multiple views of the sample

Depiction of electron tomography method

SPA (Single Particle Averaging)
in silico reconstruction of detailed 3D macromolecules using an average of many particles

3D reconstruction of Fab binding to a
virus like particle

Axial slices through a 3-D reconstruction of a virus like particle

Applications
		Drug Development: Support for pharmaceutical and biotechnology process development and formulation development and scale-up functions related to chemistry, manufacturing, and control (CMC).
		Regulatory Review: Support for demonstrating that procedures are developed to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.
		Validation: Support for demonstration of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.