Increasingly, pharmaceutical research and development is focused on understanding and anipulating the molecular mechanisms that ultimately constitute the vastly complex machinery of all living systems. Transmission electron microscopy (TEM), with its ability to directly image biological structures at the molecular scale, promises to play a crucial role in the future of drug discovery and development. (more. . . )
Researchers Clint Potter and Bridget Carragher knew that scientists needed a closer, three-dimensional look at the biomolecular structures they were working with. But it didn’t become clear there was commercial opportunity in the area until drug giant Merck & Co. sought out The Scripps Research Institute scientists for a project to characterize viruslike particles of the human papilloma virus for its recently introduced Gardasil vaccine.. (more. . . )
Enabling 3D Imaging of Macromolecular Structures Laboratory Equipment, October 2007, p.40-41
Living organisms are vastly
complex biological
machines whose functional
mechanisms operate at
the molecular and supramolecular
scale of Angstroms and
nanometers. Single-particle
imaging and analysis (SPA)
using a transmission electron
microscope (TEM) can provide
three-dimensional images of
these structures, but the utility
of the technique has been limited
by the technically difficult
and labor-intensive task of collecting
the large number of
images required for reconstruction,
and also by the sensitivity
of biological materials prone to
damage by the electron beam.
SAN DIEGO, Calif., April 19, 2010 - NanoImaging Services, Inc., announced today that it has received a Small Business Innovation Research (SBIR) grant from the National Institutes of Health through the National Center for Research Resources to develop new methods for quantitative characterization of nanoparticle morphology and aggregation state using transmission electron microscopy. The grant provides approximately $200,000 in research and development funds for a Phase I study. (more. . . )
SAN DIEGO, CA (June 30, 2009)—NanoImaging Services, Inc., a provider of
transmission electron microscopy (TEM) imaging services for the pharmaceutical and
biotechnology industries, announces the availability of an electron tomography service.
Electron tomography provides three-dimensional structural information of nanoparticles
such as viruses, liposomes or protein complexes.(more. . . )
Faster access to critical structural information has potential to accelerate development of new biopharmaceuticals
SAN DIEGO, CA (May 12, 2008)—NanoImaging Services, Inc., the leading provider of high-resolution, three-dimensional transmission electron microscope (TEM) imaging services to manufacturers of large molecule biopharmaceuticals, announces NanoImaging Data Browser, a new data delivery service that provides its customers quick, efficient and complete access to the massive data sets generated by image-based structural investigations. (more. . . )
Biopharmaceutical analytical services company expands into a 2,500 square-foot laboratory and adds staff to accommodate growing business
SAN DIEGO, Calif., March 10, 2008—NanoImaging Services, Inc., the leading provider of high-resolution, three-dimensional (3D) transmission electron microscope (TEM) imaging services to manufacturers of large molecule biopharmaceuticals, announced today that it has moved to a larger facility in La Jolla, Calif. The new 2,500-square-foot facility will enable NanoImaging Services to expand the capacity of its service laboratory and add new employees in an effort to accommodate its growing biopharmaceutical client base. (more. . . )
Funds to be used for expansion of service laboratory;
NanoImaging provides high-resolution 3D imaging of large molecule biopharmaceuticals
SAN DIEGO, Calif., February 26, 2008—NanoImaging Services, Inc., the leading provider of high-resolution, three-dimensional (3D) transmission electron microscope (TEM) imaging services to manufacturers of large molecule biopharmaceuticals, announced today that it has completed a round of financing led by Merck Capital Ventures, LLC. The $1.5 million investment will be used to expand the company’s service laboratory. NanoImaging Services, currently located in Northern San Diego, will relocate to a larger facility in La Jolla, Calif. next month.
(more. . . )
New service offers high-resolution 3D TEM imaging of large biological molecules
SAN DIEGO, CA (November 6, 2007)—NanoImaging Services, Inc. has commenced operation of a new business providing high-resolution, three-dimensional transmission electron microscope (TEM) imaging services to manufacturers of large molecule biopharmaceuticals. The service provides fast, accurate structural characterization and validation of new drug compounds, targets and assays; promising improved speed and reduced risk at all phases of the drug development process, from discovery and characterization through approval and manufacturing. (more. . . )
