Publications

2017

Barajas D, Aponte-Ubillus JJ, Akeefe H, Cinek T, Peltier J, and Gold D. 2017. Generation of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae. PLoS One. 12(3):e0173010. doi: 10.1371/journal.pone.0173010. PMCID:5371294.

Blais N, Gagne M, Hamuro Y, Rheault P, Boyer M, Steff AM, Baudoux G, Dewar V, Demers J, Ruelle JL, and Martin D. 2017. Characterization of Pre-F-GCN4t, a Modified Human Respiratory Syncytial Virus Fusion Protein Stabilized in a Noncleaved Prefusion Conformation. J Virol. 91(13):e02437-16. doi: 10.1128/JVI.02437-16. PMCID:5469252.

Chen Q, Vieth M, Timm DE, Humblet C, Schneidman-Duhovny D, Chemmama IE, Sali A, Zeng W, Lu J, and Liu L. 2017. Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages. PLoS One. 12(4):e0175758. doi: 10.1371/journal.pone.0175758. PMCID: 5391116.

Ha S, Li F, Troutman MC, Freed DC, Tang A, Loughney JW, Wang D, Wang IM, Vlasak J, Nickle DC, Rustandi RR, Hamm M, DePhillips PA, Zhang N, McLellan JS, Zhu H, Adler SP, McVoy MA, An Z, and Fu TM. 2017. Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targets Viral gH/gL/pUL128-131 Pentameric Complex. J Virol. 91(7):e02033-16. doi: 10.1128/JVI.02033-16. PMCID: 5355600.

Kasturirangan S, Rainey GJ, Xu L, Wang X, Portnoff A, Chen T, Fazenbaker C, Zhong H, Bee J, Zeng Z, Jenne C, Wu H, and Gao C. 2017. Targeted Fcgamma Receptor (FcgammaR)-mediated Clearance by a Biparatopic Bispecific Antibody. J Biol Chem. 292(10):4361-4370. doi: 10.1074/jbc.M116.770628. PMCID: 5354496.

Loughney JW, Lancaster C, Price CE, Hoang VM, Ha S, and Rustandi RR. 2017. Development of a non-radiolabeled glucosyltransferase activity assay for C. difficile toxin A and B using ultra performance liquid chromatography. J Chromatogr A. 1498:169-175. doi: 10.1016/j.chroma.2017.01.083.

Martinez-Murillo P, Tran K, Guenaga J, Lindgren G, Adori M, Feng Y, Phad GE, Vazquez Bernat N, Bale S, Ingale J, Dubrovskaya V, O’Dell S, Pramanik L, Spangberg M, Corcoran M, Lore K, Mascola JR, Wyatt RT, and Karlsson Hedestam GB. 2017. Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach. Immunity. 46(5):804-817.e7. doi: 10.1016/j.immuni.2017.04.021. PMCID:5528178.

Parupudi A, Gruia F, Korman SA, Dragulin-Otto S, Sra K, Remmele RL Jr, and Bee JS. 2017. Biophysical characterization of influenza A virions. J Virol Methods. 247:91-98. doi: 10.1016/j.jviromet.2017.06.002.

Smith G, Liu Y, Flyer D, Massare MJ, Zhou B, Patel N, Ellingsworth L, Lewis M, Cummings JF, and Glenn G. 2017. Novel hemagglutinin nanoparticle influenza vaccine with Matrix-M adjuvant induces hemagglutination inhibition, neutralizing, and protective responses in ferrets against homologous and drifted A(H3N2) subtypes. Vaccine. 35(40):5366-5372. doi: 10.1016/j.vaccine.2017.08.021.

Sun J, Remmele RL Jr, and Sanyal G. 2017. Analytical Characterization of an Oil-in-Water Adjuvant Emulsion. AAPS PharmSciTech. 18(5):1595-1604. doi: 10.1208/s12249-016-0626-8.

2016

Ali S, Sheikh S, Ahmad A, Ahmad MU, Chen P, Paithankar M, Choudhury K, Makadia RD, Kumar A, Velavan K, Satheesh CT, Singh JK, Mamillapalli G, Saptarishi D, Kale P, Patel R, Barkate HV and Ahmad I. 2016. Bioequivalence Study of Pegylated Doxorubicin Hydrochloride Liposome (PEGADRIA) and DOXIL® in Ovarian Cancer Patients: Physicochemical Characterization and Pre-clinical Studies. J Nanomed Nanotechnol. 7(2):361. doi:10.4172/2157-7439.1000361.

Flynn JA, Durr E, Swoyer R, Cejas PJ, Horton MS, Galli JD, Cosmi SA, Espeseth AS, Bett AJ, and Zhang L. 2016. Stability Characterization of a Vaccine Antigen Based on the Respiratory Syncytial Virus Fusion Glycoprotein. PLoS One. 11(10):e0164789. doi: 10.1371/journal.pone.0164789. PMCID: 5072732.

Fox CB, Orr MT, Van Hoeven N, Parker SC, Mikasa TJT, Phan T, Beebe EA, Nana GI, Joshi SW, Tomai MA, Elvecrog J, Fouts TR, and Reed SG. 2016. Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach. J Control Release. 244(Part A):98-107. doi: 10.1016/j.jconrel.2016.11.011. PMCID:5176129.

Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, Meng M, Fritz D, Vascotto F, Hefesha H, Grunwitz C, Vormehr M, Husemann Y, Selmi A, Kuhn AN, Buck J, Derhovanessian E, Rae R, Attig S, Diekmann J, Jabulowsky RA, Heesch S, Hassel J, Langguth P, Grabbe S, Huber C, Tureci O, and Sahin U. 2016. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature. 534(7607):396-401. doi: 10.1038/nature18300.

Schneemann A, Sung JJ, Speir JA, Mulligan SK, On K, Quispe J, Carragher B, and Potter CS. 2016. Structural Characterization of Monoclonal Antibody Therapeutics by Transmission Electron Microscopy and 2D Classification Analysis. Microsc Microanal. 22(S3):1082-3. doi: 10.1017/S1431927616006255.

Schneider-Ohrum K, Cayatte C, Liu Y, Wang Z, Irrinki A, Cataniag F, Nguyen N, Lambert S, Liu H, Aslam S, Duke G, McCarthy MP, McCormick L. Production of Cytomegalovirus Dense Bodies by Scalable Bioprocess Methods Maintains Immunogenicity and Improves Neutralizing Antibody Titers. J Virol. 2016;90(22):10133-44. doi: 10.1128/JVI.00463-16. PMCID: 5105651.

Vlasak J, Hoang VM, Christanti S, Peluso R, Li F, and Culp TD. 2016. Use of flow cytometry for characterization of human cytomegalovirus vaccine particles. Vaccine. 34(20):2321-8. doi: 10.1016/j.vaccine.2016.03.067.

2015

Carragher B, Schneemann A, Sung JJ, Mulligan SK, Speir JA, On K, Quispe J, and Potter CS. 2015. Electron Microscopy as an Emerging Analytical Tool for Characterizing Biopharmaceuticals. Microsc Microanal. 21(S3):65-66. doi: 10.1017/S1431927615001129

Krarup A, Truan D, Furmanova-Hollenstein P, Bogaert L, Bouchier P, Bisschop IJ, Widjojoatmodjo MN, Zahn R, Schuitemaker H, McLellan JS, and Langedijk JP. 2015. A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism. Nat Comm. 6:8143. doi: 10.1038/ncomms9143. PMCID: 4569726.

Loughney JW, Rustandi RR, Wang D, Troutman MC, Dick LW, Jr., Li G, Liu Z, Li F, Freed DC, Price CE, Hoang VM, Culp TD, DePhillips PA, Fu TM, and Ha S. 2015. Soluble Human Cytomegalovirus gH/gL/pUL128-131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes. J Biol Chem. 290(26):15985-95. doi: 10.1074/jbc.M115.652230. PMCID: 4481204.

Sitrin RD, Zhao Q, Potter CS, Carragher B, and Washabaugh MW. 2015 Recombinant Virus-like Particle Protein Vaccines in Nunally B, Turnula V, and Sitrin R (Eds.) Vaccine Analysis: Strategies, Principles, and Control. Springer. Berlin, Heidelberg. p. 81-112. doi: 10.1007/978-3-662-45024-6_3.

Sung JJ, Pardeshi NN, Mulder AM, Mulligan SK, Quispe J, On K, Carragher B, Potter CS, Carpenter JF, and Schneemann A. 2015. Transmission electron microscopy as an orthogonal method to characterize protein aggregates. J Pharm Sci. 104(2):750-59. doi: 10.1002/jps.24157. PMCID: 4376473.

Work TM, Dagenais J, Breeden R, Schneemann A, Sung J, Hew B, Balazs GH, and Berestecky JM. 2015. Green Turtles (Chelonia mydas) Have Novel Asymmetrical Antibodies. J Immunol. 195(11):5452-60. doi: 10.4049/jimmunol.1501332.

2014

Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, and Anderson DG. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc Natl Acad Sci U S A. 111(11):3955-60. doi: 10.1073/pnas.1322937111. PMCID: 3964096.

Fox CB, Mulligan SK, Sung J, Dowling QM, Fung HW, Vedvick TS, and Coler RN. 2014. Cryogenic transmission electron microscopy of recombinant tuberculosis vaccine antigen with anionic liposomes reveals formation of flattened liposomes. Int J Nanomedicine. 11;9:1367-77. doi: 10.2147/IJN.S56582. PMCID: 3956628.

Francis SM, Taylor CA, Tang T, Liu Z, Zheng Q, Dondero R, and Thompson JE. 2014. SNS01-T Modulation of eIF5A Inhibits B-cell Cancer Progression and Synergizes With Bortezomib and Lenalidomide. Mol Ther. 22(9):1643-52. doi: 10.1038/mt.2014.24. PMCID:4435495.

Linke T, Aspelund MT, Thompson C, Xi G, Fulton A, Wendeler M, Pabst TM, Wang X, Wang WK, Ram K, and Hunter AK. 2014. Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin. Biotechnol Prog. 30(6):1380-89. doi: 10.1002/btpr.1983. PMCID: 4283723.

Ma H, Galvin TA, Glasner DR, Shaheduzzaman S, and Khan AS. 2014. Identification of a novel rhabdovirus in Spodoptera frugiperda cell lines. J Virol. 88(12):6576-85. doi: 10.1128/JVI.00780-14. PMCID: 4054387.

Wagner JM, Pajerowski JD, Daniels CL, McHugh PM, Flynn JA, Balliet JW, Casimiro DR, and Subramanian S. 2014. Enhanced production of Chikungunya virus-like particles using a high-pH adapted spodoptera frugiperda insect cell line. PLoS One. 9(4):e94401. doi: 10.1371/journal.pone.0094401. PMCID: 3979839.

Zhao Q, Potter CS, Carragher B, Lander G, Sworen J, Towne V, Abraham D, Duncan P, Washabaugh MW, and Sitrin RD. 2014. Characterization of virus-like particles in GARDASIL(R) by cryo transmission electron microscopy. Hum Vaccin Immunother. 10(3):734-39. doi: 10.4161/hv.27316. PMCID: 4130261.

2013

Cayatte C, Schneider-Ohrum K, Wang Z, Irrinki A, Nguyen N, Lu J, Nelson C, Servat E, Gemmell L, Citkowicz A, Liu Y, Hayes G, Woo J, Van Nest G, Jin H, Duke G, and McCormick AL. 2013. Cytomegalovirus vaccine strain towne-derived dense bodies induce broad cellular immune responses and neutralizing antibodies that prevent infection of fibroblasts and epithelial cells. J Virol. 87(20):11107-20. doi: 10.1128/JVI.01554-13. PMCID: 3807294.

Chen C, Zhu S, Huang T, Wang S, and Yan X. 2013. Analytical techniques for single-liposome characterization. Anal Methods. 5(9):2150-57. doi: 10.1039/C3AY40219C.

Correia I, Sung J, Burton R, Jakob CG, Carragher B, Ghayur T, and Radziejewski C. 2013. The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen. mAbs. 5(3):364-72. doi: 10.4161/mabs.24258. PMCID: 4169030.

Fox CB, Barnes VL, Evers T, Chesko JD, Vedvick TS, Coler RN, Reed SG, and Baldwin SL.2013. Adjuvanted pandemic influenza vaccine: variation of emulsion components affects stability, antigen structure, and vaccine efficacy. Influenza Other Respir Viruses. 7(5):815-26. doi: 10.1111/irv.12031.

Fox CB, Moutaftsi M, Vergara J, Desbien AL, Nana GI, Vedvick TS, Coler RN, and Reed SG. 2013. TLR4 ligand formulation causes distinct effects on antigen-specific cell-mediated and humoral immune responses. Vaccine. 31(49):5848-55. doi: 10.1016/j.vaccine.2013.09.069.

Hahn TJ, Courbron D, Hamer M, Masoud M, Wong J, Taylor K, Hatch J, Sowers M, Shane E, Nathan M, Jiang H, Wei Z, Higgins J, Roh K, Burd J, Chinchilla-Olszar D, Malou-Williams M, Baskind DP, and Smith GE. 2013. Rapid Manufacture and Release of a GMP Batch of Avian Influenza A(H7N9) Virus-Like Particle Vaccine Made Using RecombinantBaculovirus-Sf9 Insect Cell Culture Technology. Bioprocess J. 12(12):4-17. doi: 10.12665/J122.Hahn.

Miranda M, Sung J, Mulligan S, On K, and Quispe J. 2013. In Vitro Characterization of Liposomal Encapsulated Doxorubicin Using CryoTEM. Controlled Release Society Newsletter. 30(3):22-24.

2012

Agadjanian H, Chu D, Hwang JY, Wachsmann-Hogiu S, Rentsendorj A, Song L, Valluripalli V, Lubow J, Ma J, Sharifi B, Farkas DL, and Medina-Kauwe LK. 2012. Chemotherapy targeting by DNA capture in viral protein particles. Nanomedicine (Lond). 7(3):335-52. doi: 10.2217/nnm.11.104. PMCID: 3429352.

Feshchenko E, Rhodes DG, Felberbaum R, McPherson C, Rininger JA, Post P, and Cox MM. 2012. Pandemic influenza vaccine: characterization of A/California/07/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability. BMC Biotechnol. 12(1):77. doi: 10.1186/1472-6750-12-77. PMCID:3538074.

Fox CB. 2012. Characterization of TLR4 agonist effects on alhydrogel(R) sedimentation: a novel application of laser scattering optical profiling. J Pharm Sci. 101(11):4357-64. doi: 10.1002/jps.23307.

Hwang JY, Lubow DJ, Chu D, Sims J, Alonso-Valenteen F, Gray HB, Gross Z, Farkas DL, and Medina-Kauwe LK. 2012. Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity. J Control Release. 163(3):368-73. doi: 10.1016/j.jconrel.2012.09.015. PMCID: 3498762.

Kale M, Suruse P, Singh R, Malhotra G, and Raut P. 2012. Effect of size reduction techniques on Doxorubicin Hydrochloride loaded liposomes. International Journal of Biological & Pharmaceutical Research. 3(3):308-16.

Mulder AM, Carragher B, Towne V, Meng Y, Wang Y, Dieter L, Potter CS, Washabaugh MW, Sitrin RD, and Zhao Q. 2012. Toolbox for non-intrusive structural and functional analysis of recombinant VLP based vaccines: a case study with hepatitis B vaccine. PLoS One. 7(4):e33235. doi: 10.1371/journal.pone.0033235. PMCID: 3320896.

Ripple DC and Dimitrova MN. 2012. Protein particles: what we know and what we do not know. J Pharm Sci. 101(10):3568-79. doi: 10.1002/jps.23242.

Schroeder A, Goldberg MS, Kastrup C, Wang Y, Jiang S, Joseph BJ, Levins CG, Kannan ST, Langer R, and Anderson DG. 2012. Remotely activated protein-producing nanoparticles. Nano Lett. 12(6):2685-89. doi: 10.1021/nl2036047. PMCID: 3388722.

Tong J, Briggs MM, and McIntosh TJ. 2012. Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity. Biophys J. 103(9):1899-908. doi: 10.1016/j.bpj.2012.09.025. PMCID: 3491688.

Willson R, Potter C, Carragher B, and Mulder AM. 2012. Cryo Transmission Electron Microscopy as an Orthogonal Tool for Characterization of Biopharmaceuticals. J Biomol Tech: JBT. 23(Suppl):S10. PMCID: 3630664.

Zhao Q, Modis Y, High K, Towne V, Meng Y, Wang Y, Alexandroff J, Brown M, Carragher B, Potter CS, Abraham D, Wohlpart D, Kosinski M, Washabaugh MW, and Sitrin RD. 2012. Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity. Virol J. 9:52. doi: 10.1186/1743-422X-9-52. PMCID: 3308208.

2011

Crawford R, Dogdas B, Keough E, Haas RM, Wepukhulu W, Krotzer S, Burke PA, Sepp-Lorenzino L, Bagchi A, and Howell BJ. 2011. Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles. Int J Pharm. 403(1-2):237-44. doi: 10.1016/j.ijpharm.2010.10.025.

2010

Richter A, Olbrich C, Krause M, and Kissel T. 2010. Solubilization of sagopilone, a poorly water-soluble anticancer drug, using polymeric micelles for parenteral delivery. Int J Pharm. 389(1-2):244-53. doi: 10.1016/j.ijpharm.2010.01.032.

Sweeney JA and Hamm C. 2010. Field flow fractionation with multiangle light scattering for measuring particle size distributions of virus-like particles, in Jameel F and Hershenson S (Eds.) Process Development Strategies for Manufacturing Biopharmaceuticals. John Wiley & Sons, Inc. Hoboken, NJ. doi: 10.1002/9780470595886.ch11.

2008

Chuan YP, Fan YY, Lua L, and Middelberg AP. 2008. Quantitative analysis of virus-like particle size and distribution by field-flow fractionation. Biotechnol Bioeng. 99(6):1425-33. doi:10.1002/bit.21710.