Publications

2017

Barajas, D., J.J. Aponte-Ubillus, H. Akeefe, T. Cinek, J. Peltier, and D. Gold. 2017. Generation of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae. PloS one. 12:e0173010.

Blais, N., M. Gagne, Y. Hamuro, P. Rheault, M. Boyer, A.M. Steff, G. Baudoux, V. Dewar, J. Demers, J.L. Ruelle, and D. Martin. 2017. Characterization of Pre-F-GCN4t, a Modified Human Respiratory Syncytial Virus Fusion Protein Stabilized in a Noncleaved Prefusion Conformation. Journal of virology. 91.

Chen, Q., M. Vieth, D.E. Timm, C. Humblet, D. Schneidman-Duhovny, I.E. Chemmama, A. Sali, W. Zeng, J. Lu, and L. Liu. 2017. Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages. PloS one. 12:e0175758.

Ha, S., F. Li, M.C. Troutman, D.C. Freed, A. Tang, J.W. Loughney, D. Wang, I.M. Wang, J. Vlasak, D.C. Nickle, R.R. Rustandi, M. Hamm, P.A. DePhillips, N. Zhang, J.S. McLellan, H. Zhu, S.P. Adler, M.A. McVoy, Z. An, and T.M. Fu. 2017. Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targets Viral gH/gL/pUL128-131 Pentameric Complex. Journal of virology.

Kasturirangan, S., G.J. Rainey, L. Xu, X. Wang, A. Portnoff, T. Chen, C. Fazenbaker, H. Zhong, J. Bee, Z. Zeng, C. Jenne, H. Wu, and C. Gao. 2017. Targeted Fcgamma Receptor (FcgammaR)-mediated Clearance by a Biparatopic Bispecific Antibody. The Journal of biological chemistry. 292:4361-4370.

Loughney, J.W., C. Lancaster, C.E. Price, V.M. Hoang, S. Ha, and R.R. Rustandi. 2017. Development of a non-radiolabeled glucosyltransferase activity assay for C. difficile toxin A and B using ultra performance liquid chromatography. Journal of chromatography. A. 1498:169-175.

Martinez-Murillo, P., K. Tran, J. Guenaga, G. Lindgren, M. Adori, Y. Feng, G.E. Phad, N. Vazquez Bernat, S. Bale, J. Ingale, V. Dubrovskaya, S. O’Dell, L. Pramanik, M. Spangberg, M. Corcoran, K. Lore, J.R. Mascola, R.T. Wyatt, and G.B. Karlsson Hedestam. 2017. Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach. Immunity. 46:804-817 e807.

Parupudi, A., F. Gruia, S.A. Korman, S. Dragulin-Otto, K. Sra, R.L. Remmele, Jr., and J.S. Bee. 2017. Biophysical characterization of influenza A virions. Journal of virological methods. 247:91-98.

Smith, G., Y. Liu, D. Flyer, M.J. Massare, B. Zhou, N. Patel, L. Ellingsworth, M. Lewis, J.F. Cummings, and G. Glenn. 2017. Novel hemagglutinin nanoparticle influenza vaccine with Matrix-M adjuvant induces hemagglutination inhibition, neutralizing, and protective responses in ferrets against homologous and drifted A(H3N2) subtypes. Vaccine. 35:5366-5372.

Sun, J., R.L. Remmele, Jr., and G. Sanyal. 2017. Analytical Characterization of an Oil-in-Water Adjuvant Emulsion. AAPS PharmSciTech. 18:1595-1604.

2016

Schneemann A, Sung JJ, Speir JA, Mulligan SK. 2016. Structural Characterization of Monoclonal Antibody Therapeutics by Transmission Electron Microscopy and 2D Classification AnalysisMicroscopy and Microanalysis 22(S3):1082-1083.

Fox CB, Orr MT, Van Hoeven N, Parker SC, Mikasa TJ, Phan T, Beebe EA, Nana GI, Joshi SW, Tomai MA, Elvecrog J, Fouts TR, Reed SG. 2016. Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach. J Control Release doi:10.1016/j.jconrel.2016.11.011.

Ali S. et al. Bioequivalence Study of Pegylated Doxorubicin Hydrochloride Liposome (PEGADRIA) and DOXIL® in Ovarian Cancer Patients: Physicochemical Characterization and Pre-clinical Studies. Journal of Nanomedicine & Nanotechnology. 2016;7(2):361.

Flynn JA, Durr E, Swoyer R, Cejas PJ, Horton MS, Galli JD, Cosmi SA, Espeseth AS, Bett AJ, Zhang L. Stability Characterization of a Vaccine Antigen Based on the Respiratory Syncytial Virus Fusion Glycoprotein. PloS one. 2016;11(10):e0164789. PMCID: 5072732.

Fox CB, Orr MT, Van Hoeven N, Parker SC, Mikasa TJT, Phan T, Beebe EA, Nana GI, Joshi SW, Tomai MA, Elvecrog J, Fouts TR, Reed SG. Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach. Journal of Controlled Release. 2016;244, Part A:98-107.

Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, Meng M, Fritz D, Vascotto F, Hefesha H, Grunwitz C, Vormehr M, Husemann Y, Selmi A, Kuhn AN, Buck J, Derhovanessian E, Rae R, Attig S, Diekmann J, Jabulowsky RA, Heesch S, Hassel J, Langguth P, Grabbe S, Huber C, Tureci O, Sahin U. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature. 2016;534(7607):396-401.

Schneemann A, Sung JJ, Speir JA, Mulligan SK, On K, Quispe J, Carragher B, Potter CS. Structural Characterization of Monoclonal Antibody Therapeutics by Transmission Electron Microscopy and 2D Classification Analysis. Microscopy and Microanalysis. 2016;22(S3):1082-3.

Schneider-Ohrum K, Cayatte C, Liu Y, Wang Z, Irrinki A, Cataniag F, Nguyen N, Lambert S, Liu H, Aslam S, Duke G, McCarthy MP, McCormick L. Production of Cytomegalovirus Dense Bodies by Scalable Bioprocess Methods Maintains Immunogenicity and Improves Neutralizing Antibody Titers. Journal of virology. 2016;90(22):10133-44. PMCID: 5105651.

Sun J, Remmele RL, Jr., Sanyal G. Analytical Characterization of an Oil-in-Water Adjuvant Emulsion. AAPS PharmSciTech. 2016.

Vlasak J, Hoang VM, Christanti S, Peluso R, Li F, Culp TD. Use of flow cytometry for characterization of human cytomegalovirus vaccine particles. Vaccine. 2016.

2015

Carragher B, Schneemann A, Sung JJ, Mulligan SK, Speir JA, On K, Quispe J, Potter CS. Electron Microscopy as an Emerging Analytical Tool for Characterizing Biopharmaceuticals. Microscopy and Microanalysis. 2015;21(S3):65-6.

Krarup A, Truan D, Furmanova-Hollenstein P, Bogaert L, Bouchier P, Bisschop IJ, Widjojoatmodjo MN, Zahn R, Schuitemaker H, McLellan JS, Langedijk JP. A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism. Nature communications. 2015;6:8143. PMCID: 4569726.

Loughney JW, Rustandi RR, Wang D, Troutman MC, Dick LW, Jr., Li G, Liu Z, Li F, Freed DC, Price CE, Hoang VM, Culp TD, DePhillips PA, Fu TM, Ha S. Soluble Human Cytomegalovirus gH/gL/pUL128-131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes. The Journal of biological chemistry. 2015;290(26):15985-95. PMCID: 4481204.

Sitrin RD, Zhao Q, Potter CS, Carragher B, Washabaugh MW. Recombinant Virus-like Particle Protein Vaccines. Vaccine Analysis: Strategies, Principles, and Control: Springer; 2015. p. 81-112.

Sung JJ, Pardeshi NN, Mulder AM, Mulligan SK, Quispe J, On K, Carragher B, Potter CS, Carpenter JF, Schneemann A. Transmission electron microscopy as an orthogonal method to characterize protein aggregates. Journal of pharmaceutical sciences. 2015;104(2):750-9. PMCID: 4376473.

Work TM, Dagenais J, Breeden R, Schneemann A, Sung J, Hew B, Balazs GH, Berestecky JM. Green Turtles (Chelonia mydas) Have Novel Asymmetrical Antibodies. Journal of immunology. 2015;195(11):5452-60.

2014

Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc Natl Acad Sci U S A. 2014;111(11):3955-60. PMCID: 3964096.

Fox CB, Mulligan SK, Sung J, Dowling QM, Fung HW, Vedvick TS, Coler RN. Cryogenic transmission electron microscopy of recombinant tuberculosis vaccine antigen with anionic liposomes reveals formation of flattened liposomes. International journal of nanomedicine. 2014;9:1367-77. PMCID: 3956628.

Francis SM, Taylor CA, Tang T, Liu Z, Zheng Q, Dondero R, Thompson JE. SNS01-T Modulation of eIF5A Inhibits B-cell Cancer Progression and Synergizes With Bortezomib and Lenalidomide. Molecular therapy : the journal of the American Society of Gene Therapy. 2014.

Linke T, Aspelund MT, Thompson C, Xi G, Fulton A, Wendeler M, Pabst TM, Wang X, Wang WK, Ram K, Hunter AK. Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin. Biotechnology progress. 2014;30(6):1380-9. PMCID: 4283723.

Ma H, Galvin TA, Glasner DR, Shaheduzzaman S, Khan AS. Identification of a novel rhabdovirus in Spodoptera frugiperda cell lines. Journal of virology. 2014;88(12):6576-85. PMCID: 4054387.

Wagner JM, Pajerowski JD, Daniels CL, McHugh PM, Flynn JA, Balliet JW, Casimiro DR, Subramanian S. Enhanced production of Chikungunya virus-like particles using a high-pH adapted spodoptera frugiperda insect cell line. PloS one. 2014;9(4):e94401. PMCID: 3979839.

Zhao Q, Potter CS, Carragher B, Lander G, Sworen J, Towne V, Abraham D, Duncan P, Washabaugh MW, Sitrin RD. Characterization of virus-like particles in GARDASIL(R) by cryo transmission electron microscopy. Human vaccines & immunotherapeutics. 2014;10(3):734-9. PMCID: 4130261.

2013

Cayatte C, Schneider-Ohrum K, Wang Z, Irrinki A, Nguyen N, Lu J, Nelson C, Servat E, Gemmell L, Citkowicz A, Liu Y, Hayes G, Woo J, Van Nest G, Jin H, Duke G, McCormick AL. Cytomegalovirus vaccine strain towne-derived dense bodies induce broad cellular immune responses and neutralizing antibodies that prevent infection of fibroblasts and epithelial cells. Journal of virology. 2013;87(20):11107-20. PMCID: 3807294.

Chen C, Zhu S, Huang T, Wang S, Yan X. Analytical techniques for single-liposome characterization. Anal Methods. 2013;5(9):2150-7.

Correia I, Sung J, Burton R, Jakob CG, Carragher B, Ghayur T, Radziejewski C. The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen. mAbs. 2013;5(3):364-72. PMCID: 4169030.

Fox CB, Barnes VL, Evers T, Chesko JD, Vedvick TS, Coler RN, Reed SG, Baldwin SL. Adjuvanted pandemic influenza vaccine: variation of emulsion components affects stability, antigen structure, and vaccine efficacy. Influenza Other Respir Viruses. 2013;7(5):815-26.

Fox CB, Moutaftsi M, Vergara J, Desbien AL, Nana GI, Vedvick TS, Coler RN, Reed SG. TLR4 ligand formulation causes distinct effects on antigen-specific cell-mediated and humoral immune responses. Vaccine. 2013;31(49):5848-55.

Hahn TJ, Courbron D, Hamer M, Masoud M, Wong J, Taylor K, Hatch J, Sowers M, Shane E, Nathan M, Jiang H, Wei Z, Higgins J, Roh K, Burd J, Chinchilla-Olszar D, Malou-Williams M, Baskind DP, Smith GE. Rapid Manufacture and Release of a GMP Batch of Avian Influenza A(H7N9) Virus-Like Particle Vaccine Made Using RecombinantBaculovirus-Sf9 Insect Cell Culture Technology. Bioprocessing Journal 2013;12(12 ).

Miranda M, Sung J, Mulligan S, On K, Quispe J. In Vitro Characterization of Liposomal Encapsulated Doxorubicin Using CryoTEM. Controlled Release Society Newsletter. 2013;30(3).

2012

Agadjanian H, Chu D, Hwang JY, Wachsmann-Hogiu S, Rentsendorj A, Song L, Valluripalli V, Lubow J, Ma J, Sharifi B, Farkas DL, Medina-Kauwe LK. Chemotherapy targeting by DNA capture in viral protein particles. Nanomedicine (Lond). 2012;7(3):335-52. PMCID: 3429352.

Feshchenko E, Rhodes DG, Felberbaum R, McPherson C, Rininger JA, Post P, Cox MM. Pandemic influenza vaccine: characterization of A/California/07/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability. BMC biotechnology. 2012;12(1):77.

Fox CB. Characterization of TLR4 agonist effects on alhydrogel(R) sedimentation: a novel application of laser scattering optical profiling. Journal of pharmaceutical sciences. 2012;101(11):4357-64.

Hwang JY, Lubow DJ, Chu D, Sims J, Alonso-Valenteen F, Gray HB, Gross Z, Farkas DL, Medina-Kauwe LK. Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity. J Control Release. 2012;163(3):368-73. PMCID: 3498762.

Kale M, Suruse P, Singh R, Malhotra G, Raut P. Effect of size reduction techniques on Doxorubicin Hydrochloride loaded liposomes. International Journal of Biological & Pharmaceutical Research. 2012;3(3):308-16.

Mulder AM, Carragher B, Towne V, Meng Y, Wang Y, Dieter L, Potter CS, Washabaugh MW, Sitrin RD, Zhao Q. Toolbox for non-intrusive structural and functional analysis of recombinant VLP based vaccines: a case study with hepatitis B vaccine. PloS one. 2012;7(4):e33235. PMCID: 3320896.

Ripple DC, Dimitrova MN. Protein particles: what we know and what we do not know. Journal of pharmaceutical sciences. 2012;101(10):3568-79.

Schroeder A, Goldberg MS, Kastrup C, Wang Y, Jiang S, Joseph BJ, Levins CG, Kannan ST, Langer R, Anderson DG. Remotely activated protein-producing nanoparticles. Nano Lett. 2012;12(6):2685-9. PMCID: 3388722.

Tong J, Briggs MM, McIntosh TJ. Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity. Biophys J. 2012;103(9):1899-908. PMCID: 3491688.

Willson R, Potter C, Carragher B, Mulder AM. Cryo Transmission Electron Microscopy as an Orthogonal Tool for Characterization of Biopharmaceuticals. Journal of Biomolecular Techniques: JBT. 2012;23(Suppl):S10.

Zhao Q, Modis Y, High K, Towne V, Meng Y, Wang Y, Alexandroff J, Brown M, Carragher B, Potter CS, Abraham D, Wohlpart D, Kosinski M, Washabaugh MW, Sitrin RD. Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity. Virol J. 2012;9:52. PMCID: 3308208.

2011

Crawford R, Dogdas B, Keough E, Haas RM, Wepukhulu W, Krotzer S, Burke PA, Sepp-Lorenzino L, Bagchi A, Howell BJ. Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles. International journal of pharmaceutics. 2011;403(1-2):237-44.

2010

Richter A, Olbrich C, Krause M, Kissel T. Solubilization of sagopilone, a poorly water-soluble anticancer drug, using polymeric micelles for parenteral delivery. International journal of pharmaceutics. 2010;389(1-2):244-53.

Sweeney JA, Hamm C. Field flow fractionation with multiangle light scattering for measuring particle size distributions of virus-like particles. Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals. 2010:253.

2008

Chuan YP, Fan YY, Lua L, Middelberg AP. Quantitative analysis of virus-like particle size and distribution by field-flow fractionation. Biotechnol Bioeng. 2008;99(6):1425-33.