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| The Challenge: Protein Complex Characterization |
| Direct determination of protein or protein complex morphology for therapeutic proteins is critical to characterization during pharmaceutical and biotechnology process development and formulation. |
| The Solution: CryoTEM (Transmission Electron Microscopy) |
| CryoTEM allows for the direct visualization of macromolecules in their native hydrated state, avoiding the artifacts associated with alternative preparation methods like negative staining or freeze fracture. |
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Image of bacteriophage () acquired at a magnification of 52,000x.
Capsids that are full vs. empty can be readily distinguished. |
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