A clearer understanding of nanoscale particles and how they interact with other molecules is extremely valuable to the development of therapeutic applications. Three dimensional structures can be constructed in silico using TEM images, but the method can be technically difficult and labor intensive.
The Solution: Single Particle Analysis using CryoTEM
Using advanced automated data collecting methods developed by the founders of NanoImaging Services, detailed 3D structures can be generated through combining cryoTEM images from a large number of identical particles.
CryoTEM image of Human Papilloma virus like particles (left) and three-dimensional reconstruction using SPA methods.
Three-dimensional reconstruction of Fab binding on Human Papilloma virus like particles
Case Studies
10931 North Torrey Pines Road, # 108La Jolla, CA 92037 P: 888.675.8261 F: 888.675.8261info@nanoimagingservices.com
