Virus and Virus Like Particle Characterization
Direct determination of the morphology, size distribution, shape and concentration of stock solution of viruses and virus vaccines is vital for sample characterization during pharmaceutical and biotechnology process development and formulations analysis. NanoImaging Services performs full characterization of viruses and virus vacines using advanced transmission electron microscopy methods.
|Human Adenovirus Serotype 5 preserved in vitreous ice.
||Human Papilloma virus like particles preserved in vitreous ice.
- Morphology Characterization
Determination of particle shape and size distribution
- Titer Determination
The concentration of the stock solution of a given sample is readily determined from TEM images for suitable samples
- 3D Structure
In silico reconstruction of detailed 3D virus or VLP model
Case Studies: Read more about our virus and virus like particle characterization services in the "Characterization of Viruses and Vaccines: Adeno5 and H1N1" and "Characterization of Biopharmaceuticals: Gardisil" case studies.
Drug Development: Support for pharmaceutical and biotechnology process development and formulation development and scale-up functions related to chemistry, manufacturing, and control (CMC).
Regulatory Review: Support for demonstrating that procedures are developed to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.
Validation: Visual demonstration of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.