Virus and Virus Like Particle Characterization
Direct determination of virus and virus like particles (VLPs) morphology, size distribution, and shape is vital for sample characterization during pharmaceutical and biotechnology process development and formulations analysis. NanoImaging Services performs full characterization of nanoscale viral and virus like particles using advanced Molecular Microscopy methods developed specifically to preserve the native biological structure.
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| Human Adenovirus Serotype 5 preserved in vitreous ice. |
Human Papilloma virus like particles preserved in vitreous ice. |
- Morphology Characterization
Determination of particle shape and size distribution
- Statistical Characterization
Typing of virus particles using advanced statistical analysis methods
- 3D Structure
In silico reconstruction of detailed 3D virus or VLP model
Applications
Case Studies: Read more about our virus and virus like particle characterization services in the "Characterization of Viruses and Vaccines: Adeno5 and H1N1" and "Characterization of Biopharmaceuticals: Gardisil" case studies.
Drug Development: Support for pharmaceutical and biotechnology process development and formulation development and scale-up functions related to chemistry, manufacturing, and control (CMC).
Regulatory Review: Support for demonstrating that procedures are developed to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.
Validation: Visual demonstration of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.
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