Sizing and Counting 

 
Accurately defining the size distribution of particles in a given sample is essential for characterization during pharmaceutical and biotechnology process development, formulation and production.  Standard nanoparticle sizing methods such as dynamic light scattering (DLS) can be plagued by biases introduced by contaminants. NanoImaging Services has developed advanced Molecular Microscopy image analysis software for semi-automated particle sizing and contouring that provides precise, statistically determined, and accurate sample size distribution measurement for nanometer to sub-micron particles in heterogeneous and homogeneous sample solutions.
 
Molecular Microscopy images of two different serotypes of Human Papilloma virus like particles before (left) and after (right) particle sizing Image-based particle sizing results in characteristic curves specific to serotype
  • Size Distribution of the Sample
    Does the size distribution compare with other batches or lots?
  • Biosimilarity
    Is the size distribution similar to existing formulations?
     
  • Direct Measurement
    Is the actual size comparable to indirect measurements?
 
Applications

Case Studies: Read more about our sizing and counting services in the "Characterization of Biopharmaceuticals: Gardisil" case study.

Drug Development: Support for pharmaceutical and biotechnology formulation discovery, development and scale-up functions related to chemistry, manufacturing, and control (CMC).

Regulatory Review: Provide supplemental and potential critical data for demonstrating procedures to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.

Validation: Qualified evidence of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

Get the latest news, product information, tips and industry insight and from our staff of professionals.
 
 
Company
Our Story
FCOI Policy
Services
Overview
Sizing and Counting
Sub-micron Aggregate
Characterization

Liposome and Emulsion
Characterization

Proteins and Protein
Complex Characterization

Virus and Virus Like Particle
Characterization

3D Structure Determination
Technology
Overview
Specimen Preparation
Sample Requirements
Microscope Control and
Automation

Data Tracking and
Delivery
Case Studies
Overview
Characterization of
Liposomes in Solution

Characterization of Biopharmaceuticals:
Gardasil®

Characterization of
Viruses and Vaccines: Adeno5 and H1N1

Sub-micron Aggregate
Characterization: IgG and IgM
Customer Service
Overview
How to Order Services
Request a Quotation
Purchase Orders
Expedited Turnaround Time
Payment and Payment Terms
Submit Samples
News & Events
Press Release
In the News
Newsletters
Events
Publications
Contact Us
888.675.8261
info@nanoimagingservices.com