3D Structure Determination
Three dimensional structural determination can answer questions about drug products and therapeutics that are not accessible by traditional methods. What is the lamellarity of your micelle preparation? Where on your drug delivery vehicle are the receptor proteins located? What is the encapsulation efficiency for your drug product? NanoImaging Services performs three dimensional structural determinations of nanoscale structures using advanced tomography or single particle averaging (SPA) methods developed specifically to extract important information from drug product preparations.
|3D structure of Adenovirus Serotype 5 calculated from molecular microscopy images.
||3D reconstruction of Liposomal encapsulated Doxorubicin reveal particle assembly and capsulation efficiency.
- Lamellarity Determination
How many continuous lipid layers do your liposomes or micelles contain?
- Drug Delivery Vehicle Characterization
What is the distribution of receptor proteins on your drug delivery vehicle?
- Drug Product Encapsulation
Has your drug product been efficiently encapsulated?
Read more about our 3D structure determination services in the "Characterization of Biopharmaceuticals: Gardisil
," "Characterization of Viruses and Vaccines: Adeno5 and H1N1
," and "Characterization of Liposomes in Solution
" case studies.
Support for pharmaceutical and biotechnology process development and formulation development and scale-up functions related to chemistry, manufacturing, and control (CMC).
Regulatory Review: Support for demonstrating that procedures are developed to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.
Validation: Support for demonstration of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.