Services Overview

NanoImaging Services provides Molecular Microscopy imaging and analysis of samples in solution.
Sizing and Counting

  • Virus Like Particles
  • Liposomes and Micelles
  • Titer Determination
  • Empty vs. Full
  • Capsulation Efficiency
Standard nanoparticle sizing methods such as dynamic light scattering (DLS) can be plagued by biases introduced by contaminants.  Direct visualization of nanoparticles in solution by Molecular Microscopy methods allows exact determination of particle size, shape, and count. Read more >>

Sub-micron Aggregate Characterization

  • Direct Measure
  • Sub-micron to Nano Scale
  • Size and Shape
  • % Loss of Soluble Protein
Thorough characterization of sub-micron aggregates contained in drug products is increasingly important, but standard methods such as size exclusion chromatography (SEC) and dynamic light scattering (DLS) are indirect and fall short when it comes to the really small stuff.  Visualization of sub-micron aggregate particulates in solution by Molecular Microscopy gives a direct measure of aggregation.
Liposome and Emulsion Characterization
  • Size
  • Shape
  • Lamellarity
  • Stability and Preservation
  • Capsulation Efficiency
  • Particle Assembly
Nanoparticle delivery systems pose characterization challenges in formulation development. NanoImaging Services has defined state of the art Molecular Microscopy methods to characterize liposome and polymeric micelle formulations. Our studies provide a direct observation and measurement of size, shape, lamellarity, stability, and degree of aggregation. Our services have assisted nanoparticle formulation discovery, development and commercialization. Read more >>

Proteins and Protein Complex Characterization

  • Morphology
  • Degree of Aggregation
  • Formulations
  • Antibody Labeling
  • Adjuvant Interactions
  • 3D Structure
Direct visualization of proteins and protein complexes in solution can save hundreds of thousands of dollars spent in time and reagents during process development and formulation analysis.  NanoImaging Services performs full characterization of proteins and protein complexes in solution using state of the art Molecular Microscopy methods developed specifically to preserve the native structure of your sample and provide a direct measure of protein and protein complex morphology, aggregation state, and structure.  Our services have assisted in the development of protein drug product formulations. Read more >>

Virus and Virus Like Particle Characterization

  • Content
  • Concentration
  • Morphology
  • Sizing and Counting
  • Lot to lot comparisons
  • Biosimilarity
Molecular Microscopy is the method of choice for the characterization of viruses, virus like particles (VLP), vaccines and vaccine adjuvants. NanoImaging Services studies provide visual quantification of content, concentration, morphology, particle size, lot to lot comparisons, and biosimilarity. Our services have benefited vaccine development in preclinical and CMC manufacturing studies. Read more >>

3D Structure Determination

  • Particle Volume
  • 3D Shape
  • Lamellarity
  • Encapsulation efficiency
  • Aggregate characterization
  • Epitope localization
Three dimensional structural determination can answer questions about your drug product that are not accessible by traditional methods.  NanoImaging Services performs three dimensional structural determinations of nanoscale structures using advanced tomography or single particle averaging (SPA) methods developed specifically to extract important information from drug product preparations.  Our services have served as an important factor in passing regulatory during drug development. Read more >>

Service Levels
  • Preview services provide a small sample of images for preliminary assessment.
  • Automated data collection services provide a statistical sampling of the specimen.
  • Analysis services include particle characterization and 3D structure.
  • Direct, rapid and convenient data access via secure online web portal.
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Our Story
FCOI Policy
Sizing and Counting
Sub-micron Aggregate

Liposome and Emulsion

Proteins and Protein
Complex Characterization

Virus and Virus Like Particle

3D Structure Determination
Specimen Preparation
Sample Requirements
Microscope Control and

Data Tracking and
Case Studies
Characterization of
Liposomes in Solution

Characterization of Biopharmaceuticals:

Characterization of
Viruses and Vaccines: Adeno5 and H1N1

Sub-micron Aggregate
Characterization: IgG and IgM
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