Characterization of Viruses and Vaccines: Adeno5 and H1N1


The Challenge: Characterization of Virus and Vaccine Drug Products

A clearer understanding of nanoscale particles and how they interact with other molecules is extremely valuable to the development of therapeutic applications. Three dimensional structures can be constructed in silico using Molecular Microscopy images, but the method can be technically difficult and labor intensive. 

The Solution: Single Particle Analysis using Molecular Microscopy

Using advanced automated data collecting methods developed by the founders of NanoImaging Services, detailed 3D structures can be generated through combining Molecular Microscopy images from a large number of identical particles.
 
Molecular Microscopy image and 3D structure of human adenovirus serotype 5 at 52,000x magnification.

Negative stain Molecular Microscopy image of H1N1 (influenza) vaccine at 52,000x magnification. (Courtesy, MedImmune, Inc.)

 
 
3D structure of Adenovirus Serotype 5 calculated from Molecular Microscopy images.  
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